pensyarah universiti
jabatan sains biologi & bioteknologi
hisham@ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
This research explores alternative sources of stem cells in blood and dental pulp tissue, their potential applications, and the development of biomarkers for various purposes. The findings hold promise for advancing stem cell research and potentially reducing orthodontic treatment time. Notably, dental pulp stem cells as compared to peripheral blood stem cells displayed a higher tendency to become nerve compared to bone cells and cartilage cells. Additionally, studies identified enzyme activity profiles in blood and saliva as potential biomarkers for monitoring bone cell development, tooth movement, and orthodontic treatment progress. Moreover, new, safer methods for cytotoxicity analysis were developed using these stem cells, replacing commonly used cancer cell lines. Beyond these research contributions, also produces numerous publications, awards, and students mentored. Overall, it demonstrates significant potential for advancements in stem cell applications, diagnostics, and potentially improving orthodontic treatment efficiency.
shahrul hisham zainal ariffin. (2025). highland flora to regenerative medicine: exploring piper sarmentosum's osteogenic potential through natural cell activation . - simposium kebangsaan kepelbagaian biologi dan persekitaran tanah tinggi 2025. .
l. mageswary a/p lapchmanan, ahmad fahmi lim abdullah, mahenderan appukutty, chang kah haw,anwar bin norazit, mohd nazil bin salleh, asmaa' binti suid, wan syafira binti ishak, saiful adli bin jamaluddin mohd normani bin zakaria siti suriani binti che husin muhammad shafiq imran anual nurulamin bin abu bakar zuliana binti razali baskaran gunasekaran shamala salvamani nur adeela binti yasid zariyantey binti abd hamid abdah binti md akim reezal bin ishak ng wen jie adela ida anak jiram jamilah hanum binti abdul khaiyom lim hooi shan alvin ng lai oon ponnusamy subramaniam low jia liang noorhaizad bin ithnin rosli bin abdul hamid mohd farouk bin mubarak abdul rahman bin mustaffa chua kah hoay zulfitri ‘azuan bin mat daud nik shanita binti safii nor azwani binti mohd shukri kanimolli a/p arasu hasliza binti hassan abdul hafiz bin ab majid salmah binti yaakop mohd khadri bin shahar norasmah binti basari noor aslinda ummi binti awang besar dr. siti shahara binti zulfakar mohamad azhar bin mohd noor rozaini binti abdullah zakaria bin hamid siti rolizawati binti mamat rus dina binti rus din revathi rajan eva tan lee yin khairul adli bin nikman saira bahnu binti mohamed yousoof ng ching ching shahrul hisham bin zainal ariffin nor khatijah binti mohd aris farah amalina binti mohd zulkufli zaikiah binti mohd zin khairulnissa binti abdul kadir caryn chan mei hsien ajau danis wee lei hum siau ching sin kamarul amin bin abdullah @ abu bakar zanariah binti mohd norhayati binti mohd zain elza azri bin othman mohammad mudzakir bin zainal alam emida binti mohamed mohd nizam bin zahary mohd nazif bin samat @ darawi santhra segaran a/l balan boob pa a/p init jeannie wong hsiu ding mohd hafiz bin mohd zin yeong chai hong parimalah velo mohd ariff bin mohamed hanifa yap wei boon chia suet lin kenny voon gah leong hanani norlina binti mahpudz azhanazura binti abdul rahman wong jyh eiin mohd redzwan bin sabran norliyana binti aris chong hueh zan megan vaidehi ulaganathan harnisha binti haidhir padma binti a rahman farahiyah binti wan yunus muthuraman a/l sellathurai pathar tengku mohd asri bin tengku makhtar mohd haidzir bin abdul manaf nor azlin binti mohd nordin maria justine@ stephany mahadevi a/p muthurethina barathi nazatul sima binti arum shah nor aniza binti azmi muhammad safwan bin ahmad fadzil muhammad afiq bin khairil anuar siti adawiah binti abu bakar santhekumari a/p sithamparam hasherah binti mohd. ibrahim khairy anuar bin mohd khairuddin rahayu mustaffa kamal nor shahrina binti mohd zawawi faith ng peik hwa puspawati binti mohamed saravanakumar a/l maniam nur alia binti zarmani shah rizan binti muhamad sadri. (2025). programme standards medical and health sciences 2025. - . .
intan zarina zainol abidin, yamuna silvaraja, shahrul hisham zainal ariffin. (2025). southeast asian medicinal plants in osteoporosis: a systematic review of anti-osteoclastogenesis in preclinical models. - sains malaysiana. 3215 - 3226.
vaishnave a/p loga raju, siti zahidah binti zahari, shahrul hisham zainal ariffin, rus dina rus din, intan zarina zainol abidin, rohaya megat abdul wahab. (2025). kajian sistematik dan penentuan kumpulan haplo berdasarkan mutasi hotspot di gen mt-nd1 pada dna mitokondria manusia. - undergraduate research journal for biological sciences and biotechnology. 20 - 28.
lee chie how, lee xiao qing, rohaya megat abdul wahab, farinawati yazid, nur atmaliya luchman, shahrul hisham zainal ariffin. (2025). pengesahan kertas penapis whatman gred 595 sebagai kertas serapan untuk persampelan cecair krevis gingiva. - sains malaysiana. 403 - 414.
jun hong steven tan, farinawati yazid, nurfathiha abu kasim, shahrul hisham zainal ariffin, rohaya megat abdul wahab. (2024). a newly developed kit for dental apical root resorption detection: efficacy and acceptability. - bmc oral health. 1-9.
shahrul hisham zainal ariffin, rohaya megat abdul wahab, muhammad abdul razak, muhammad dain yazid, muhammad ashraf shahidan, azizi miskon, intan zarina zainol abidin. (2024). evaluation of in vitro osteoblast and osteoclast differentiation from stem cell: a systematic review of morphological assays and staining techniques. - peerj. 1 - 22.
milton hongli tsai, rohaya megat abdul wahab, shahrul hisham zainal ariffin, fazren azmi, farinawati yazid. (2023). enhanced osteogenesis potential of mg-63 cells through sustained delivery of vegf via liposomal hydrogel. - gels. 1-17.
intan zarina zainol abidin, anis nabilah johari, muhammad dain yazid, zaidah zainal ariffin, herryawan ryadi eziwar dyari, shahrul hisham zainal ariffin. (2023). osteogenic potential and bioactive profiles of piper sarmentosum ethanolic extract-treated stem cells. - pharmaceuticals. 1-15.
nor idayu a. rahman, chung liang lam, nadiah sulaiman, nur atiqah haizum abdullah, fazlina nordin, shahrul hisham zainal ariffin, muhammad dain yazid. (2023). pax7, a key for myogenesis modulation in muscular dystrophies through multiple signaling pathways: a systematic review. - international journal of molecular sciences. 1-21.
intan zarina zainol abidin, roa m.a. aliwaisi, zulham yamamoto, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). osteogenic potential in piper sarmentosum roxb.: a systematic review of in vitro and in vivo evidence. - sains malaysiana. 1875 - 1887.
lee chie how, lee xiao qing, rohaya megat abdul wahab, farinawati yazid, nur atmaliya luchman, shahrul hisham zainal ariffin. (2025). pengesahan kertas penapis whatman gred 595 sebagai kertas serapan untuk persampelan cecair krevis gingiva. - sains malaysiana. 403 - 414.
intan zarina zainol abidin, yamuna silvaraja, shahrul hisham zainal ariffin. (2025). southeast asian medicinal plants in osteoporosis: a systematic review of anti-osteoclastogenesis in preclinical models. - sains malaysiana. 3215 - 3226.
shahrul hisham bin zainal ariffin, lim koon seang, intan zarina zainol abidin, rohaya megat abdul wahab, ramzah dambul. (2024). analisis tinjauan sistematik kesan iklim dan altitud tinggi terhadap variasi dna nuklear dan mitokondria manusia. - sains malaysiana . 3327 - 3340.
shahrul hisham zainal ariffin, rohaya megat abdul wahab, thanaletchumi manogaran, farinawati yazid, siti nur zahidah zahari, rus dina rus din, intan zarina zainol abidin. (2023). protein rembesan sel stem pulpa gigi susu manusia (shed) semasa pembezaan kepada sel osteoblas. - sains malaysiana. 1771-1783.
intan zarina zainol abidin, yamuna silvaraja, shahrul hisham zainal ariffin. (2025). southeast asian medicinal plants in osteoporosis: a systematic review of anti-osteoclastogenesis in preclinical models. - sains malaysiana. 3215 - 3226.
lee chie how, lee xiao qing, rohaya megat abdul wahab, farinawati yazid, nur atmaliya luchman, shahrul hisham zainal ariffin. (2025). pengesahan kertas penapis whatman gred 595 sebagai kertas serapan untuk persampelan cecair krevis gingiva. - sains malaysiana. 403 - 414.
intan zarina zainol abidin, roa m.a. aliwaisi, zulham yamamoto, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). osteogenic potential in piper sarmentosum roxb.: a systematic review of in vitro and in vivo evidence. - sains malaysiana. 1875 - 1887.
shahrul hisham bin zainal ariffin, lim koon seang, intan zarina zainol abidin, rohaya megat abdul wahab, ramzah dambul. (2024). analisis tinjauan sistematik kesan iklim dan altitud tinggi terhadap variasi dna nuklear dan mitokondria manusia. - sains malaysiana . 3327 - 3340.
shahrul hisham zainal ariffin, rohaya megat abdul wahab, muhammad abdul razak, muhammad dain yazid, muhammad ashraf shahidan, azizi miskon, intan zarina zainol abidin. (2024). evaluation of in vitro osteoblast and osteoclast differentiation from stem cell: a systematic review of morphological assays and staining techniques. - peerj. 1 - 22.
m.n.m. zain , z.m. yusof , f. yazid , a. ashari , k.s.h. wong , w.j. lee , k.f. tan , s.h.z. ariffin and r.m.a wahab. (2020). absorption spectrum analysis of dentine sialophosphoprotein (dspp) in orthodontic patient. - the 2nd international conference on applied photonics and electronics 2019 (incape 2019) aip conference proceedings. 1-6.
farinawati yazid, mohd norzaliman mohd zain, zalhan md yusof, fairul syazwani hj. ghazali, siti aisyah zulkifli, najah mohd nadri, shahrul hisham zainal ariffin and rohaya megat abdul wahab. (2020). caries detection analysis in human saliva alpha amylase. - the 2nd international conference on advance photonics and electronic (incape 2019). 1-7.
farah amirah mohd nasri, rohaya megat abdul wahab, saiful anuar karsani, and shahrul hisham zainal ariffin. (2016). differences of protein profile before and after orthodontic treatment. - the 2016 ukm fst postgraduate colloquium, aip conference proceeding. 1-4.
shahrul hisham zainal ariffin, thanaletchumi manogaran, intan zarina zainol abidin, sahidan senafi, rohaya megat abdul wahab. (2016). isolation and morphology of stem cells from deciduous tooth (shed) and human dental pulp stem cells (hdpsc). - the 2016 ukm fst postgraduate colloquium, aip conference proceeding. 1-5.
siti norhaiza hadzir, rohaya megat abdul razak, intan zarina zainol abidin, shahrul hisham zainal ariffin. (2013). in vitro expansion of lin+ and lin- mononuclear cells from human peripheral blood. - aip conference proceedings - proceedings of the universiti kebangsaan malaysia, faculty of science and technology 2013 postgraduate colloquium. .
intan zarina zainol abidin, puteri haslin nadya hasbullah, shahrul hisham zainal ariffin. (2018). kesan aktiviti sitotoksik piper sarmentosum ke atas sel titisan mc33- e1 dan potensi pembezaannya kepada sel osteoblas. - . 189-192.
rus dina rus din, nursyafiqah zafira mahyasi, rohaya megat abdul wahab, shahrul hisham zainal ariffin. (2018). penentuan umur individu berdasarlan pengukuran kaviti pulpa gigi pramolar pertama melalui pendekatan drusini dan kvaal. - . 193-196.
shahrul hisham zainal ariffin, nur akmal mohamed rozali, intan zarina zainol abidin & rohaya megat abdul wahab. (2017). sensitivity of alkaline phosphatase as an osteoblast differentiation marker for dental pulp stem cells in 2d versus 3d cultures. - . 79-87.
rohaya megat abdul wahab, zulham yamamoto, intan zarina zainol abidin & shahrul hisham zainal ariffin. (2017). diagnostic accuracy of lactate dehydrogenase as prognostic marker for external apical root resorption. - . 1-15.
shahana parveen ridzam shah rajah, thanaletchumi manogaran, intan zarina zainal abidin & shahrul hisham zainal ariffin. (2017). sititoksisiti ekstrak akues piper sarmentosum dan asid askorbik ke atas sel titisan mc3t3-e1 dan potensi pembezaannya kepada sel osteoblas. - . 374-378.
vaishnave a/p loga raju, siti zahidah binti zahari, shahrul hisham zainal ariffin, rus dina rus din, intan zarina zainol abidin, rohaya megat abdul wahab. (2025). kajian sistematik dan penentuan kumpulan haplo berdasarkan mutasi hotspot di gen mt-nd1 pada dna mitokondria manusia. - undergraduate research journal for biological sciences and biotechnology. 20 - 28.
shahrul hisham zainal ariffin, intan zarina zainol abidin, asmah awal, rohaya megat abdul wahab.. (2025). herba malaysia: bahan semulajadi untuk kelestarian kehidupan. - rencana bulanan pkaukm. .
lee chie how, lee xiao qing, rohaya megat abdul wahab, farinawati yazid, nur atmaliya luchman, shahrul hisham zainal ariffin. (2025). pengesahan kertas penapis whatman gred 595 sebagai kertas serapan untuk persampelan cecair krevis gingiva. - sains malaysiana. 403 - 414.
shahrul hisham zainal ariffin, ameedtri tha wip sripraphan, siti nur zahidah zahari, rus dina rus din, intan zarina zainol abidin. (2024). penentuan kumpulan haplo manusia pada gen mt-nd2 dna mitokondria. - simposium biologi kebangsaan ke-10 2023. 6-10.
shahrul hisham bin zainal ariffin, rus dina rus din, rohaya megat abdul wahab. (2024). kapal karam wanli di perairan dungun, terengganu. - rencana bulanan pkaukm : siri 3/2024. .
shahrul hisham zainal ariffin. (2025). highland flora to regenerative medicine: exploring piper sarmentosum's osteogenic potential through natural cell activation . - simposium kebangsaan kepelbagaian biologi dan persekitaran tanah tinggi 2025. .
l. mageswary a/p lapchmanan, ahmad fahmi lim abdullah, mahenderan appukutty, chang kah haw,anwar bin norazit, mohd nazil bin salleh, asmaa' binti suid, wan syafira binti ishak, saiful adli bin jamaluddin mohd normani bin zakaria siti suriani binti che husin muhammad shafiq imran anual nurulamin bin abu bakar zuliana binti razali baskaran gunasekaran shamala salvamani nur adeela binti yasid zariyantey binti abd hamid abdah binti md akim reezal bin ishak ng wen jie adela ida anak jiram jamilah hanum binti abdul khaiyom lim hooi shan alvin ng lai oon ponnusamy subramaniam low jia liang noorhaizad bin ithnin rosli bin abdul hamid mohd farouk bin mubarak abdul rahman bin mustaffa chua kah hoay zulfitri ‘azuan bin mat daud nik shanita binti safii nor azwani binti mohd shukri kanimolli a/p arasu hasliza binti hassan abdul hafiz bin ab majid salmah binti yaakop mohd khadri bin shahar norasmah binti basari noor aslinda ummi binti awang besar dr. siti shahara binti zulfakar mohamad azhar bin mohd noor rozaini binti abdullah zakaria bin hamid siti rolizawati binti mamat rus dina binti rus din revathi rajan eva tan lee yin khairul adli bin nikman saira bahnu binti mohamed yousoof ng ching ching shahrul hisham bin zainal ariffin nor khatijah binti mohd aris farah amalina binti mohd zulkufli zaikiah binti mohd zin khairulnissa binti abdul kadir caryn chan mei hsien ajau danis wee lei hum siau ching sin kamarul amin bin abdullah @ abu bakar zanariah binti mohd norhayati binti mohd zain elza azri bin othman mohammad mudzakir bin zainal alam emida binti mohamed mohd nizam bin zahary mohd nazif bin samat @ darawi santhra segaran a/l balan boob pa a/p init jeannie wong hsiu ding mohd hafiz bin mohd zin yeong chai hong parimalah velo mohd ariff bin mohamed hanifa yap wei boon chia suet lin kenny voon gah leong hanani norlina binti mahpudz azhanazura binti abdul rahman wong jyh eiin mohd redzwan bin sabran norliyana binti aris chong hueh zan megan vaidehi ulaganathan harnisha binti haidhir padma binti a rahman farahiyah binti wan yunus muthuraman a/l sellathurai pathar tengku mohd asri bin tengku makhtar mohd haidzir bin abdul manaf nor azlin binti mohd nordin maria justine@ stephany mahadevi a/p muthurethina barathi nazatul sima binti arum shah nor aniza binti azmi muhammad safwan bin ahmad fadzil muhammad afiq bin khairil anuar siti adawiah binti abu bakar santhekumari a/p sithamparam hasherah binti mohd. ibrahim khairy anuar bin mohd khairuddin rahayu mustaffa kamal nor shahrina binti mohd zawawi faith ng peik hwa puspawati binti mohamed saravanakumar a/l maniam nur alia binti zarmani shah rizan binti muhamad sadri. (2025). programme standards medical and health sciences 2025. - . .
som chit,c., zainal ariffin,s.h., zahari,s.n.z., rus din,r.d., zainol abidin,i.z. and abdul wahab,r.m.. (2025). homo sapiens isolate vaish3 cytochrome c oxidase subunit i (cox1) gene, partial cds;mitochondrial. - . .
som chit,c., zainal ariffin,s.h., zahari,s.n.z., rus din,r.d., zainol abidin,i.z. and abdul wahab,r.m.. (2025). homo sapiens isolate cas1 cytochrome c oxidase subunit i (cox1) gene, partial cds;mitochondrial. - . .
shahrul hisham zainal ariffin, intan zarina zainol abidin, asmah awal, rohaya megat abdul wahab.. (2025). herba malaysia: bahan semulajadi untuk kelestarian kehidupan. - rencana bulanan pkaukm. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| DENTAL ROOT RESORPTION DIAGNOSTIC KIT COMMERCIAL PRODUCTION FOR CLINICAL READY MARKET | vivantis technologies sdn bhd. | 93.1% (2023-11-01 sehingga 2026-02-28) |
| UNRAVELLING SUBCELLULAR DYNAMICS OF RICTOR FOR ACTIN REMODELLING IN DUCHENNE MUSCULAR DYSTROPHY (DMD) | ming medical services sdn bhd | 90.1% (2023-10-01 sehingga 2026-03-31) |
| UNRAVELLING SUBCELLULAR DYNAMICS OF RICTOR FOR ACTIN REMODELLING IN DUCHENNE MUSCULAR DYSTROPHY (DMD) | malaysian rare disorders society (mrds) | 90.1% (2023-10-01 sehingga 2026-03-31) |
| IN-VITRO EVALUATION OF EXOSOME-HYALURONIC ACID SYNERGY IN ORAL WOUND HEALING | wari technologies sdn. bhd. | 58.3% (2024-11-01 sehingga 2026-10-31) |
BIOTECHNOLOGY :PURE AND APPLIED SCIENCES
Peripheral Blood Stem Cells, Dental Pulp Stem Cells, Cytotoxicity, Molecular Biology, Molecular Archaeology, Cell Biology, Enzymology, Tooth Movement, Biomarkers, Genomics and Sequencing,,,,,,,,,
Pengalaman / Experience : tahun/years(s)