pensyarah universiti
pusat kajian toksikologi & risiko kesihatan (core)
satirah@ukm.edu.my
Biografi/ Biography :
Saya telah menjalani pengkhususan di dalam bidang fisiologi dan farmakologi kardiovaskular, dengan penumpuan ke atas mekanisme kecederaan kardiovaskular dan potensi intervensi terapeutik. Penyelidikan kami menggunakan pelbagai jenis model haiwan, termasuk kecederaan jantung yang disebabkan oleh isoprenalin dan nikotin, untuk menyelidiki laluan yang terlibat dalam kerosakan jantung. Salah satu bidang minat utama saya ialah potensi terapeutik tumbuhan perubatan dan sebatian bioaktif. Kajian kami telah meneroka kesan ekstrak kaya antosianin daripada roselle (Hibiscus sabdariffa), glikosida kardio 17β-neriifolin daripada Cerbera odollum, dan S-allylcysteine daripada bawang putih, dengan tujuan untuk mengenal pasti sifat kardioprotektif dan mekanisme tindakannya. Penyelidikan ini telah menyumbang kepada pemahaman dan bukti bahawa penggunaan sebatian semula jadi mempunyai potensi di dalam terapi kardiovaskular. Di dalam makmal, kami mempelopori pelbagai teknik, terutamanya sistem perfusi jantung terasing menggunakan alat Langendorff—satu teknik yang satu-satunya aktif di dalam bidang penyelidikan kardiovaskular di Malaysia. Selain itu, kami juga mengkaji kereaktifan vaskular, tapak jalan protein, dan ekspresi gen untuk lebih memahami fungsi dan penyakit kardiovaskular.
I specialize in cardiovascular physiology and pharmacology, with a strong focus on unravelling the mechanisms of cardiovascular injury and exploring potential therapeutic interventions. Our research involves utilizing animal models, such as isoprenaline-induced and nicotine-induced cardiac injury, to gain insights into the intricate pathways of heart damage. An area of particular interest is the therapeutic potential of medicinal plants and bioactive compounds. Our work has explored the effects of anthocyanin-rich extracts from roselle (Hibiscus sabdariffa), the cardiac glycoside 17β-neriifolin from Cerbera odollum, and S-allylcysteine, a sulfur-containing compound derived from garlic. These studies aim to uncover their cardioprotective properties and mechanisms of action. I am proficient in advanced laboratory techniques, with a primary focus on the isolated perfused heart system using the Langendorff apparatus—a technique that stands out as the only active cardiovascular research approach in Malaysia. Additionally, I am involved in research on vascular reactivity and investigating protein and gene expression pathways to deepen our understanding of cardiovascular regulation and potential drug targets.
chee hooi chung, mohammad yusuf hasan, satirah zainalabidin, chua eng wee, azizah ugusman, zakiah jubri, mohd kaisan mahadi. (2025). modulation of a7nachr for cardioprotection against isoprenaline-induced myocardial injury. - sains malaysiana. 3727 - 3740.
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
jun kiat, mahadir ahmad, caryn mei hsien chan, satirah zainalabidin, michael ungar, ponnusamy subramaniam. (2025). effectiveness of adaptation of a resilience-building intervention among individuals with adverse childhood experience: protocol for a randomized controlled trial. - jmir research protocols. 150 - 164.
jie lee, muhamad adib abdul ghani, satirah zainalabidin. (2025). effects of s-allyl cysteine on vascular reactivity in ovariectomized rats. - revista brasileira de farmacognosia. 486 - 490.
rony abdi syahputra, helen helen, mega carensia gunawan, zahirah dhiya utari, aminah dalimunthe, emil salim, marianne bastian, nurpudji astuti taslim, pipit pitriani, sony eka nugraha, putri cahaya situmorang, fahrul nurkolis, satirah zainalabidin. (2025). eriobotrya japonica a review: phytochemical constituents, traditional uses, and therapeutic potentials. - journal of agriculture and food research. 1 - 21.
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
rajasegar anamalley, yusof kamisah, nurhanan murni yunos, satirah zainalabidin. (2025). 17ßh-neriifolin improves cardiac remodeling through modulation of calcium handling proteins in the heart failure rat model. - biomedicines. 1 - 16.
urip harahap, rony abdi syahputra, amer ahmed, azhari nasution, wenny wisely, maureen lazurit sirait, aminah dalimunthe, satirah zainalabidin, nurpudji astuti taslim, fahrul nurkolis, bonglee kim. (2024). current insights and future perspectives of flavonoids: a promising antihypertensive approach. - phytotherapy research. 3146-3168.
rini retnosari, amatul hamizah ali, satirah zainalabidin, azizah ugusman, natsuhisa oka, jalifah latip. (2024). the recent discovery of a promising pharmacological scaffold derived from carvacrol: a review. - bioorganic and medicinal chemistry letters. 1 - 28.
rini retnosari, kentaro oh-hashi, azizah ugusman, satirah zainalabidin, jalifah latip, natsuhisa oka. (2024). carvacrol-conjugated 3-hydroxybenzoic acids: design, synthesis, cardioprotective potential against doxorubicin-induced cardiotoxicity, and admet study. - bioorganic & medicinal chemistry letters. 1 - 9.
chee hooi chung, mohammad yusuf hasan, satirah zainalabidin, chua eng wee, azizah ugusman, zakiah jubri, mohd kaisan mahadi. (2025). modulation of a7nachr for cardioprotection against isoprenaline-induced myocardial injury. - sains malaysiana. 3727 - 3740.
jie lee, muhamad adib abdul ghani, satirah zainalabidin. (2025). effects of s-allyl cysteine on vascular reactivity in ovariectomized rats. - revista brasileira de farmacognosia. 486 - 490.
fatin farhana jubaidi, nur liyana mohammed yusof, satirah zainalabidin, izatus shima taib, zariyantey abd hamid & siti balkis budin. (2024). determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model . - sains malaysiana. 1321 - 1332.
fatin farhana jubaidi, satirah zainalabidin, izatus shima taib, zariyantey abdul hamid, siti balkis budin. (2022). pemodelan semula jantung dalam kardiomiopati diabetes: peranan inflamasi, tekanan oksidatif dan apoptosis yang mendasari pembentukan dan perkembangannya. - sains malaysiana. 4043-4057.
rajasegar anamalley, logeswary rajassageran, yasaaswini apparoo, muhammad haffiz jauri, yusof kamisah, nurhanan murni yunos, satirah zainalabidin. (2022). repeated administration of low dose isoprenaline on the rat's cardiovascular system. - sains malaysiana. 2147-2157.
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
jie lee, muhamad adib abdul ghani, satirah zainalabidin. (2025). effects of s-allyl cysteine on vascular reactivity in ovariectomized rats. - revista brasileira de farmacognosia. 486 - 490.
rony abdi syahputra, helen helen, mega carensia gunawan, zahirah dhiya utari, aminah dalimunthe, emil salim, marianne bastian, nurpudji astuti taslim, pipit pitriani, sony eka nugraha, putri cahaya situmorang, fahrul nurkolis, satirah zainalabidin. (2025). eriobotrya japonica a review: phytochemical constituents, traditional uses, and therapeutic potentials. - journal of agriculture and food research. 1 - 21.
chee hooi chung, mohammad yusuf hasan, satirah zainalabidin, chua eng wee, azizah ugusman, zakiah jubri, mohd kaisan mahadi. (2025). modulation of a7nachr for cardioprotection against isoprenaline-induced myocardial injury. - sains malaysiana. 3727 - 3740.
rajasegar anamalley, yusof kamisah, nurhanan murni yunos, satirah zainalabidin. (2025). 17ßh-neriifolin improves cardiac remodeling through modulation of calcium handling proteins in the heart failure rat model. - biomedicines. 1 - 16.
anand ramalingam, norsyahida mohd. fauzi, siti balkis budin, rebecca ritchie, satirah zainalabidin. (2020). angiotensin ii type i receptor antagonism prevents nicotine-induced cardiac dysfunction in rats. - 23rd world congress of the international-society-for-heart-research (ishr). 8.
yanti rosli, asmah hamid, mazlyzam abdul latif, nur najmi mohamad anuar, satirah zainal abidin, siti fathiah masre. (2025). covid-19: faktor risiko status kesihatan. - . 53 - 84.
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). potensi rosel ke atas sistem kardiovaskular. - . 77-93.
satirah zainalabidin, rumaisak farizal, shafreena shaukat ali & siti balkis budin. (2021). kesan ekstrak akueus rosel terhadap sistem kardiovaskular. - . 22-37.
satirah zainalabidin, farah wahida ibrahim & siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi tahap praklinikal. - . 17-21.
satirah zainalabidin, siti fathiah masre & farah wahida ibrahim. (2021). prospek hasilan semula jadi di dalam perubatan klinikal. - . 107-112.
yanti rosli, asmah hamid, mazlyzam abdul latif, nur najmi mohamad anuar, satirah zainal abidin, siti fathiah masre. (2025). covid-19: faktor risiko status kesihatan. - . 53 - 84.
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). potensi rosel ke atas sistem kardiovaskular. - . 77-93.
yap wei boon;satirah binti zainalabidin. (2022). development and mechanism of action of np-ha2-m2e influenza universal vaccine in promoting humoral and cell-mediated immunity.. - . .
fatin farhana jubaidi, satirah zainalabidin, izatus shima taib, zariyantey abdul hamid, siti balkis budin. (2022). pemodelan semula jantung dalam kardiomiopati diabetes: peranan inflamasi, tekanan oksidatif dan apoptosis yang mendasari pembentukan dan perkembangannya. - sains malaysiana. 4043-4057.
satirah zainalabidin, siti fathiah masre & farah wahida ibrahim. (2021). prospek hasilan semula jadi di dalam perubatan klinikal. - . 107-112.
stephenie tamil many, rajasegar anamalley, satirah zainalabidin, nurzafirah mazlan, sasimalani surgunnam, mohd fikri akmal mohd khodzori, dawood shah . (2024). the effects of red sea marine sponge (xestospongia testudinaria) on hemodynamic and histopathological in heart failure rats . - 1st international conference on cardiovascular and quality of life. .
muhamad adib abdul ghani, mohd kaisan mahadi, norliza muhamad, satirah zainalabidin. (2024). the cardioprotective potential of sac on regional ischemia-reperfusion in ovariectomized rat’s heart . - 1st international conference on cardiovascular and quality of life. .
satirah zainalabidin. (2024). cardiac structural changes via antioxidant status in ovariectomized rats with induced myocardial injury . - 1st international conference on cardiovascular and quality of life. .
satirah zainalabidin, muhamad adib abdul ghani, lee jie, mohd kaisan mahadi, norliza muhammad. (2024). elucidating s-allyl-l-cysteine impact to the heart function and vascular reactivity in estrogen-deficiency rats. - international conference on integrative physiology and molecular medicine. .
satirah zainalabidin, muhamad adib abdul ghani, mohd kaisan mahadi, norliza muhamad . (2024). s-allylcysteine attenuates regional ischemia/reperfusion injury in estrogen-deficient model. - 1st annual scientific meeting of the international society of heart research southeast asia section (ishr-sea) . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| THE CARDIOPROTECTIVE POTENTIAL OF S-ALLYL-L-CYSTEINE (SAC) IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN OVARIECTOMIZED RATS | labquip (adinstrument malaysia) | 85.8% (2023-10-01 sehingga 2025-12-31) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | resilience research centre | 97.7% (2022-10-01 sehingga 2025-09-30) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | thrive well | 97.7% (2022-10-01 sehingga 2025-09-30) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | dr. michael ungar | 97.7% (2022-10-01 sehingga 2025-09-30) |
| EFFECTS OF GUNDELIA TOURNEFORTII L. ON CALCINEURIN–NFAT–GATA4 PATHWAY IN ANGIOTENSIN II-INDUCED HYPERTROPHIED CARDIOMYOCYTES IN VITRO | university of jordan | 21.5% (2025-04-01 sehingga 2027-03-31) |