pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
effendisy@ppukm.ukm.edu.my
Biografi/ Biography :
Saiful Effendi Syafruddin is a Research Fellow/Senior Lecturer at the UKM Medical Molecular Biology Institute (UMBI). He holds PhD in Medical Sciences from the University of Cambridge, UK. He previously earned his Master’s in Biotechnology (Molecular Genetic) from the University of Pennsylvania, USA, and BSc. in Biotechnology from Rochester Institute of Technology, USA. His PhD project focused on elucidating the genetic and epigenetic determinants that support kidney cancer pathogenesis. Saiful Effendi research interest revolves around understanding cancer molecular dependencies, specifically in kidney cancer, with the aim to identify novel and efficient clinical strategies to fight against cancer. Having been trained in the field of cell and molecular biology, cancer biology and genetic engineering for more than a decade, he has been extensively utilizing various state-of-the-art laboratory techniques throughout his cancer research works. Several of his research works have been published in high impact journals such as Nature, Cancer Discovery, Nature Communication, and Cell.
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shamsul azhar shah, nao suzuki, abdul kadir abdul karim. (2025). comparison of cumulus cells preparation among diminished ovarian reserved and normal ovarian reserved women for rna extraction and review of literature. - medicine & health. 525 - 545.
nur syakirah othman, amilia aminuddin, shahidee zainal abidin, saiful effendi syafruddin, mohd faizal ahmad, adila a. hamid, azizah ugusman. (2025). metformin alters the microrna profile of high glucose induced human umbilical vein endothelial cells. - medicine and health. 667 - 685.
nurul iffah mohd isa, aslah nabilah abdull sukor, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, mohd helmy mokhtar, azizah ugusman, adila a. hamid. (2025). rna sequencing-based profiling of differentially expressed micrornas in endothelial cells from offspring of hypertensive pregnancies: a preliminary study. - frontiers in molecular biosciences. 1 - 17.
mohd faizal ahmad, nurul yaqin mohd nor, mohammad mahmoud mohammad ramadneh, nurul izyani roseli, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shah shamsul azhar, nao suzuki, abdul kadir abdul karim . (2025). comparative analysis of rescue-in vitro-maturation (r-ivm) outcomes in women with diminished ovarian reserve (dor) versus normal ovarian reserve (nor). - biomedicines. 1 - 13.
nurul iffah mohd isa, aslah nabilah abdull sukor, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, mohd helmy mokhtar, azizah ugusman, adila a. hamid. (2025). rna sequencing-based profiling of differentially expressed micrornas in endothelial cells from offspring of hypertensive pregnancies: a preliminary study. - frontiers in molecular biosciences. 1 - 17.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
ahmad mohd faizal, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu saiful effendi syafruddin, ani amelia zainuddin, nao suzuki and abdul kadir abdul karim. (2024). unravelling the role of has2, grem1, and ptgs2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. - frontiers in endocrinology. 1-12.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
muhammad bani yamin, fazleen haslinda mohd hatta , mohd shafiq aazmi, saiful effendi syafruddin, michelle yee shuen lee, nurul hanis ramzi ,nikman adli nor hashim and nazia abdul majid. (2025). unravelling putative ethnic-specific obesity genetic loci in malaysian youths: a genome-wide association study. - southeast asian journal of tropical medicine and public health. 253 - 290.
kelly xue jing jong, elsa haniffah mejia mohamed, saiful effendi syafruddin, farid nazer faruqu, kumutha malar vellasamy, kamariah ibrahim, zaridatul aini ibrahim. (2024). il-8 and pi3k pathway influence the susceptibility of trail-sensitive colorectal cancer cells to trail-induced cell death. - molecular biology reports. 1 - 10.
poh kuan wong, saiful effendi syafruddin, fook choe cheah, norazrina azmi, pei yuen ng, eng wee chua. (2024). introduction of a single-nucleotide variant, rs16851030, into the adora1 gene increased cellular susceptibility to hypoxia. - personalized medicine. 353 - 366.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, nao suzuki, shamsul azhar shah, abdul kadir abdul karim. (2024). gene expression profiling of hyaluronic acid synthetase 2 (has2), prostaglandin-endoperoxide synthase 2 (ptgs2) and gremlin 1 (grem1) in cumulus cells among women with diminished ovarian reserved (dor). - mjm vol 79 supplement 3, july 2024 . 7 - 7.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
mohd faizal ahmad, nurul yaqin mohd nor, mohammad mahmoud mohammad ramadneh, nurul izyani roseli, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shah shamsul azhar, nao suzuki, abdul kadir abdul karim . (2025). comparative analysis of rescue-in vitro-maturation (r-ivm) outcomes in women with diminished ovarian reserve (dor) versus normal ovarian reserve (nor). - biomedicines. 1 - 13.
muhammad bani yamin, fazleen haslinda mohd hatta , mohd shafiq aazmi, saiful effendi syafruddin, michelle yee shuen lee, nurul hanis ramzi ,nikman adli nor hashim and nazia abdul majid. (2025). unravelling putative ethnic-specific obesity genetic loci in malaysian youths: a genome-wide association study. - southeast asian journal of tropical medicine and public health. 253 - 290.
nurul iffah mohd isa, aslah nabilah abdull sukor, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, mohd helmy mokhtar, azizah ugusman, adila a. hamid. (2025). rna sequencing-based profiling of differentially expressed micrornas in endothelial cells from offspring of hypertensive pregnancies: a preliminary study. - frontiers in molecular biosciences. 1 - 17.
nurul nadia mohamad zamberi, siti nur hasanah mohd yusufb m. aiman mohtar, saiful effendi syafruddin. (2025). uncovering the transcription factor network driving klf6 expression through super enhancers in renal cell carcinoma. - asian pacific journal of molecular biology and biotechnology. 17 - 17.
muhammad-redha abdullah-zawawi, shing cheng tan, m. aiman mohtar, saiful effendi syafruddin, teck yew low, muhammad irfan abdul jalal. (2025). unveiling cancer complexity: machine learning insights into multi-omics data. - . 51 - 69.
aminah suhaila haron, saiful e. syafruddin, ilie fadzilah hashim, muggunna balasubramaniam, saw keat chuan, yasmin hasnizan, nurul syafawani fizal, chong chien fung, ana masara ahmad mokhtar. (2023). genetic mutations and clinical diagnoses associated with increased risk of malignancy in primary immunodeficiencies. - . 235-251.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). penyahkawalseliaan proses transkripsi dalam patogenesis kanser. - majalah dewan kosmik. 50-53.
nor azian abdul murad, nor azila muhammad azami, saiful effendi syafruddin, & razinah sharif. (2022). corona id 1.0 - pemerkasaan literasi kesihatan terhadap pelajar sekolah semasa era pandemik covid19. - knovasi kongres dan pertandingan inovasi dalam pengajaran dan pembelajaran. 1.
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2022). bengkel crispr gene editing di institute of medical research (imr). - . 1-3.
saiful effendi syafruddin. (2025). rogue cells : the story of cancer. - seminar pengajaran kolaboratif cidl uitm . .
adila a hamid, aslah nabilah, abdull sukor, azizah ugusman, mohd faizal ahmad, nur fariha, mohd manzor, shahidee zainal abidin. (2025). mir-196a-5p modulates angiogenesis-related protein expression in human umbilical vein endothelial cells from hypertensive pregnancies.. - 5th international conference on advances in medical science . .
adila a hamid, nurul iffah mohd isa, saiful effendi syafruddin, amilia aminuddin, shahidee zainal abidin, mohd faizal ahmad, azizah ugusman. (2025). profiling of upregulated mirnas in endothelial cells exposed to hypertensive disorders of pregnancy: a bioinformatic analysis . - 38th scientific meeting of the malaysian society of pharmacology . .
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
nurul iffah mohd isa, saiful effendi syafruddin, shahidee zainal abidin, mohd faizal ahmad, mohd helmy mokhtar, azizah ugusman, adila a hamid. (2025). the role of mir-196a-5p in regulating inflammation-related genes in human umbilical vein endothelial cells exposed to hypertensive pregnancy. - the 8th global public health conference . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| INVESTIGATING ENGINEERED NANOVESICLE CAPTURING AGENT AGAINST PRO-ANGIOGENIC VEGFA IN RENAL CARCINOMA | genscript biotech (singapore) private limited | 50.8% (2025-03-03 sehingga 2026-03-02) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | nanoarms sdn. bhd. | 77.2% (2023-10-01 sehingga 2026-03-31) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | genomax technologies sdn bhd | 77.2% (2023-10-01 sehingga 2026-03-31) |