pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
chinsiokfong@ukm.edu.my
Biografi/ Biography :
Dr. Chin Siok-Fong memperoleh Sarjana Muda (Kepujian) Sains Bioperubatan dari Universiti Kebangsaan Malaysia pada tahun 2004 dan dianugerahkan Ijazah Doktor Falsafah dalam Sains Perubatan (pengkhususan Biokimia) dari universiti yang sama pada tahun 2011.
Beliau pakar dalam analisis bioanalisis biomolekul berkaitan klinikal menggunakan platform berbilang omik. Fokus penyelidikan beliau tertumpu pada penemuan biopenanda kanser dan biologi kanser, daripada mengkaji mekanisme pelbagai biomolekul kepada pembangunan biomolekul tersebut sebagai peramal risiko untuk kanser kolorektal, paru-paru dan payudara. Beliau juga meneroka rangkaian komunikasi antara hos dan patogen dalam kanser kolorektal melalui pendekatan mikrobiom dan sekretom usus. Selama bertahun-tahun, beliau terlibat secara aktif dalam membangunkan kaedah bioanalisis baharu untuk melengkapi kajian klinikal seperti pengesanan pelbagai molekul kecil, ubat-ubatan dan molekul plastik (phthalates) menggunakan spektrometri jisim dan kromatografi cecair berprestasi tinggi. Beliau juga telah mengambil bahagian dalam percubaan klinikal dan kajian biokesetaraan. Terbaharu, beliau sedang menyiasat kemungkinan penggunaan molekul sintetik baharu daripada oligonukleotida yang mimik kepada antibodi (juga dikenali sebagai aptamer) sebagai alternatif yang lebih baik berbanding antibodi konvensional, sebagai komponen utama dalam ujian diagnostik baharu.
Keupayaan Dr. Chin dalam membangunkan kaedah bioanalisis baharu untuk kajian klinikal telah menarik minat daripada pihak industri untuk mengadakan kolaborasi penyelidikan. Dengan kerjasama tersebut, beliau kini menggabungkan kecerdasan buatan dalam mewujudkan model ramalan risiko baharu berasaskan unsur surih beserta aplikasi enjin kalkulator risiko untuk pemeriksaan awal kanser paru-paru tanpa gejala.
Dr. Chin Siok Fong obtained her BSc. (Hons) Biomedical Sciences from Universiti Kebangsaan Malaysia in 2004 and conferred a PhD in Medical Sciences (major in Biochemistry) from the same university in 2011.
She specializes in bioanalytical analysis of clinically related biomolecules using multi-omics platforms. Her current research interests focused on cancer biomarker discovery and cancer biology, from studying the molecular mechanisms to establishing various biomolecules as potential risk predictor for colorectal, lung and breast cancers. She also explored communication network between host and pathogen in colorectal cancer via gut microbiome and secretome approaches. Over the years, she was (and still is) actively involved in developing new bioanalytical methods to complement clinical studies such as detection of numerous small molecules, drugs, and plasticisers (phthalates) using mass spectrometry and high performance liquid chromatography. She has also participated in human intervention trial and bioequivalence study. Currently, she is investigating the possible application of new synthetic molecules mimicking antibodies from oligonucleotides also known as aptamer as a better alternative to conventional antibodies, as the central component for new diagnostic assays.
Dr. Chin’s strong ability in developing new bioanalytical method for clinical studies had attracted some interest from the industry. With the collaboration, she is currently incorporating artificial intelligence in establishing a novel trace element-based risk prediction model and its platform for early screening of asymptomatic lung cancer.
maelinda daker, munirah ahmad, alan soo-beng khoo, lu ping tan, siok-fong chin, siaw san hwang, paul m. neilsen. (2025). silvestrol inhibits nasopharyngeal carcinoma cells and synergizes with cx-5461: insights from a proteomics study. - molecular and clinical oncology. 1 - 14.
nor akma mohamad, chin siok fong, doris lau sie chong. (2025). mapping the gut microbiota changes during induction chemotherapy in paediatric acute leukaemia patients. - 19th st jude-viva forum. .
muhammad irfan abdul jalal, ahmad termidzi mohd azhar, mohd arman kamruddin, mohd raziff alias, nazihah abd jalal, norliza ismail, chin siok-fong, goh ying-xian, noraidatulakma abdullah, ismail sagap, zairul azwan mohd azman, azimatun noor aizuddin, azmawati mohammed nawi, nor halizam ismail, rahman jamal, nor azian abdul murad.. (2025). colorectal cancer screening using immunochemical faecal occult blood testing (ifobt) in urban-poor communities in cheras, malaysia: a cross-sectional study. - malaysian journal of medical sciences. 154 - 168.
anis adibah osman, siok-fong chin, lay-kek teh, noraidatulakma abdullah, nor azian abdul murad, rahman jamal. (2025). lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation. - heliyon. 1 - 15.
muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, nor afiqah-aleng, shah-jahan kamal-chinakarppen, nur alyaa afifah md shahri, siti aishah sulaiman, siok fong chin, zeti-azura mohamed-hussein, rahman jamal, nor azian abdul murad. (2025). bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method. - journal of diabetes & metabolic disorders. 1 - 16.
ainin sofia jusoh, muhammad akmal remli, mohd saberi mohamad, tristan cazenave, chin siok fong . (2025). how generative artificial intelligence can transform drug discovery?. - european journal of medicinal chemistry. 1 - 21.
anis adibah osman, siok-fong chin, lay-kek teh, noraidatulakma abdullah, nor azian abdul murad, rahman jamal. (2025). lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation. - heliyon. 1 - 15.
maryam fatimah abu bakar, siok fong chin, suzana makpol, jen kit tan, azmawati mohammed nawi. (2024). diagnostic performance of serum metabolites biomarker associated with colorectal adenoma: a systematic review. - peerj. 1 - 14.
holly bihun, noraidatulakma abdullah, nor azian abdul murad, chin siok fong, azwa shawani kamalul arifin, aisyatul najihah khuzaimi, fredrik karpe, sarah lewington, jennifer carter, fiona bragg, rahman jamal. (2024). body fat distribution and bone mineral density in a multi-ethnic sample of postmenopausal women in the malaysian cohort. - archives of osteoporosis. 1 - 10.
maryam fatimah abu bakar, azmawati mohammed nawi, siok fong chin and suzana makpol. (2024). current status of serum metabolites biomarkers for polyps and colorectal cancer: a systematic review. - gastroenterology report. 1 - 10.
afreena afiqah azman, chin siok fong, nor fadilah rajab, reena rahayu md zin, nurul nadiah ahmad daud, ezanee azlina mohamad hanif. (2023). the potential roles of lncrna tincr in triple negative breast cancer. - molecular biology reports. 7909-7917.
muhammad nur adam hatta; ezanee azlina mohamad hanif; siok-fong chin; teck yew low; hui-min neoh. (2023). parvimonas micra infection enhances proliferation, wound healing, and inflammation of a colorectal cancer cell line. - bioscience reports. 1-13.
azmawati mohammed nawi, siok-fong chin, shamsul azhar shah, rahman jamal. (2019). tissue and serum trace elements concentration among colorectal patients: a systematic review of case control studies. - iranian journal of public health. 632-643.
siok fong chin, putri intan hafizah megat mohd azlan, luqman mazlan and hui min neoh. (2018). identification of schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study. - gut pathogens. 1-3.
xin-ee tan, hui-min neoh, mee-lee looi, siok fong chin, longzhu cui, keiichi hiramatsu, salasawati hussin and rahman jamal. (2017). activated adi pathway: the initiator of intermediate vancomycin resistance in staphylococcus aureus. - canadian journal of microbiology. 1-5.
maelinda daker, munirah ahmad, alan soo-beng khoo, lu ping tan, siok-fong chin, siaw san hwang, paul m. neilsen. (2025). silvestrol inhibits nasopharyngeal carcinoma cells and synergizes with cx-5461: insights from a proteomics study. - molecular and clinical oncology. 1 - 14.
muhammad irfan abdul jalal, ahmad termidzi mohd azhar, mohd arman kamruddin, mohd raziff alias, nazihah abd jalal, norliza ismail, chin siok-fong, goh ying-xian, noraidatulakma abdullah, ismail sagap, zairul azwan mohd azman, azimatun noor aizuddin, azmawati mohammed nawi, nor halizam ismail, rahman jamal, nor azian abdul murad.. (2025). colorectal cancer screening using immunochemical faecal occult blood testing (ifobt) in urban-poor communities in cheras, malaysia: a cross-sectional study. - malaysian journal of medical sciences. 154 - 168.
anis adibah osman, siok-fong chin, lay-kek teh, noraidatulakma abdullah, nor azian abdul murad, rahman jamal. (2025). lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation. - heliyon. 1 - 15.
muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, nor afiqah-aleng, shah-jahan kamal-chinakarppen, nur alyaa afifah md shahri, siti aishah sulaiman, siok fong chin, zeti-azura mohamed-hussein, rahman jamal, nor azian abdul murad. (2025). bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method. - journal of diabetes & metabolic disorders. 1 - 16.
ainin sofia jusoh, muhammad akmal remli, mohd saberi mohamad, tristan cazenave, chin siok fong . (2025). how generative artificial intelligence can transform drug discovery?. - european journal of medicinal chemistry. 1 - 21.
ooi ting kee, harmiza harun, norlaila mustafa, nor azian abdul murad, siok fong chin, rosmina jaafar, hamat hamdi che hassan, mohd zubir suboh, noraidatulakma abdullah. (2023). cardiovascular disease risk in type 2 diabetes mellitus prediction model development using machine learning. - ieee international conference on artificial intelligence in engineering and technology (iicaiet). 61-65.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
noraidatulakma binti abdullah @ muda;norlaila binti mustafa;nor azian binti abdul murad;chin siok fong;rosmina jaafar. (2024). establishment of cardiovascular-diabetes prediction model by lipid peroxidation markers. - . .
siok-fong chin. (2022). aplikasi kepintaran buatan dalam meramal kanser paru-paru berasaskan unsur mineral dalam badan - mampukah ia menjadi realiti?. - . 1.
ying -xian goh, noraidatulakma abdullah, nurul ain mhd yusuf, mohd arman kamaruddin & chin siok-fong. (2021). ujian komposisi badan dengan pengimejan absorptiometri dwi-tenaga (dxa/ dexa). - the malaysian cohort. 1.
chin siok-fong. (2021). kenali mikrobiom usus anda. - dewan kosmik. 24-26.
azmawati mohammed nawi, rahman jamal, chin siok fong. (2020). unsur mineral dalam darah dan risiko kanser. - . 184.
nor akma mohamad, chin siok fong, doris lau sie chong. (2025). mapping the gut microbiota changes during induction chemotherapy in paediatric acute leukaemia patients. - 19th st jude-viva forum. .
chin siok fong;ezanee azlina binti mohamad hanif;nor adzimah binti johdi. (2024). elucidating lysosomal autophagy mechanism in lrg1-mediated colorectal cancer. - . .
ezanee azlina mohamad hanif, afreena afiqah azman, chin siok-fong, nor fadilah rajab, reena rahayu md zin, adi syazni mohammed, norlia abdullah, nani harlina md latar . (2024). functional characterisation and prognostic features of tincr in triple negative breast cancer. - 4th international conference on dental, medical & health sciences. .
ezanee azlina mohamad hanif, afreena afiqah azman, siok-fong chin, nor fadilah rajab, reena rahayu md zin, adi syazni mohammed, norlia abdullah, nani harlina md latar . (2024). tincr: the key regulator to chemoresistant in triple negative breast cancer (tnbc). - translational and holistic medicine conference 2024. .
noraidatulakma binti abdullah @ muda;norlaila binti mustafa;nor azian binti abdul murad;chin siok fong;rosmina jaafar. (2024). establishment of cardiovascular-diabetes prediction model by lipid peroxidation markers. - . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| DECIPHERING THE INTER-LINKAGE ROLE OF VITAMIN D AND LEUCINE-RICH α-2 GLYCOPROTEIN 1 (LRG1) IN 5-FLUOROURACIL CHEMORESISTANT COLORECTAL CANCER: A CLINICAL ASSESSMENT | bio-diagnostic sdn bhd | 77.2% (2023-10-01 sehingga 2026-03-31) |