Biografi/ Biography :
Dr. Hamizah Shahirah Hamezah is a research fellow at the Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM). She graduated from Universiti Kebangsaan Malaysia with Bachelor of Science in Genetics (Hons.) and Master in Medical Science (Biochemistry). She completed her Ph.D. in Medical Science at Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan, under the supervision of Professor Dr. Ikuo Tooyama and Associate Professor Dr. Daijiro Yanagisawa. Upon completing her Ph.D., she was appointed as an Assistant Professor at the Department of Diagnostics and Therapeutics for Brain Diseases, Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan. She has a great interest in understanding the mechanisms of learning and memory, as well as interventions for the cognitive decline during aging and neurodegenerative diseases. Her researches focus on finding possible biomarkers leading to the cognitive decline in brain aging and Alzheimer’s disease by using the state-of-art omics approaches, brain imaging, and cognitive neurosciences. She is also interested in finding possible therapeutics for the treatment of neurodegenerative diseases by investigating the effect of natural compounds on the transgenic animal models.
mohamed a. farag, nurkhalida kamal, hamizah shahirah hamezah, merna saleh, jiachao zhang, ahmed mediani, mostafa h. baky. (2025). the role of microorganisms and microbial enzymes in commercial fermented mushroom production: a comprehensive review of their action mechanisms, quality attributes and health benefits. - food production, processing and nutrition. 1 - 13.
nur irlia sofea mohammad zamani, faidruz azura jam, liew jia yi, chua wan yi, tharani rajendran, pearlyne willie wong, april tang yee ying, ummi kalthum azlan, hamizah shahirah hamezah, ahmed mediani, emelda rosseleena rohani. (2025). advancing alzheimer's therapy with moringa oleifera: bioactive insights, mechanistic pathways, and strategies for efficacy and standardization. - the open medicinal chemistry journal. 1 - 15.
shasha sun, hamizah shahirah hamezah, chuanshan jin, rongchun han, xiaohui tong. (2025). albiflorin on neuropsychiatric and neurodegenerative disorders: a systematic review. - cns neuroscience & therapeutics. 1 - 13.
yuxin shan, hongjian shen, ling huang, hamizah shahirah hamezah, rongchun han, xia ren, chunhong zhang, xiaohui tong. (2025). optimized maxent analysis revealing the change of potential distribution area of lygodium japonicum in china driven by global warming. - frontiers in plant science. 1 - 13.
siti norliyana zubaidi, pei lou wong, wasim s.m. qadi, esraa adnan dawoud dawoud, hamizah shahirah hamezah, syarul nataqain baharum, faidruz azura jam, faridah abas, andres moreno, ahmed mediani. (2025). deciphering the mechanism of annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with 1h-nmr-based metabolomics approach. - journal of pharmaceutical and biomedical analysis. 1 - 15.
shasha sun, hamizah shahirah hamezah, chuanshan jin, rongchun han, xiaohui tong. (2025). albiflorin on neuropsychiatric and neurodegenerative disorders: a systematic review. - cns neuroscience & therapeutics. 1 - 13.
yuxin shan, hongjian shen, ling huang, hamizah shahirah hamezah, rongchun han, xia ren, chunhong zhang, xiaohui tong. (2025). optimized maxent analysis revealing the change of potential distribution area of lygodium japonicum in china driven by global warming. - frontiers in plant science. 1 - 13.
siti norliyana zubaidi, pei lou wong, wasim s.m. qadi, esraa adnan dawoud dawoud, hamizah shahirah hamezah, syarul nataqain baharum, faidruz azura jam, faridah abas, andres moreno, ahmed mediani. (2025). deciphering the mechanism of annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with 1h-nmr-based metabolomics approach. - journal of pharmaceutical and biomedical analysis. 1 - 15.
nur aisyah khairul annuar, ummi kalthum azlan, ahmed mediani, xiaohui tong, rongchun han, ebtesam al-olayan, syarul nataqain baharum, hamidun bunawan, murni nazira sarian, hamizah shahirah hamezah, ibrahim jantan. (2024). an insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine. - biomedicine & pharmacotherapy. 1-16.
chenyu zhou, quan xia, hamizah shahirah hamezah, zheng fan, xiaohui tong, rongchun han. (2024). efficacy of forsythia suspensa (thunb.) vahl on mouse and rat models of inflammation-related diseases: a meta-analysis. - frontiers in pharmacology. 1-11.
chenyu zhou, lanmeng yan, jing xu, hamizah shahirah hamezah, tongsheng wang, fangping du, xiaohui tong, rongchun han. (2024). phillyrin: an adipose triglyceride lipase inhibitor supported by molecular docking, dynamics simulation, and pharmacological validation. - journal of molecular modeling. 1-10.
mohamed a. farag, nurkhalida kamal, hamizah shahirah hamezah, merna saleh, jiachao zhang, ahmed mediani, mostafa h. baky. (2025). the role of microorganisms and microbial enzymes in commercial fermented mushroom production: a comprehensive review of their action mechanisms, quality attributes and health benefits. - food production, processing and nutrition. 1 - 13.
nur irlia sofea mohammad zamani, faidruz azura jam, liew jia yi, chua wan yi, tharani rajendran, pearlyne willie wong, april tang yee ying, ummi kalthum azlan, hamizah shahirah hamezah, ahmed mediani, emelda rosseleena rohani. (2025). advancing alzheimer's therapy with moringa oleifera: bioactive insights, mechanistic pathways, and strategies for efficacy and standardization. - the open medicinal chemistry journal. 1 - 15.
siti norliyana zubaidi, pei lou wong, wasim s.m. qadi, esraa adnan dawoud dawoud, hamizah shahirah hamezah, syarul nataqain baharum, faidruz azura jam, faridah abas, andres moreno, ahmed mediani. (2025). deciphering the mechanism of annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with 1h-nmr-based metabolomics approach. - journal of pharmaceutical and biomedical analysis. 1 - 15.
shasha sun, hamizah shahirah hamezah, chuanshan jin, rongchun han, xiaohui tong. (2025). albiflorin on neuropsychiatric and neurodegenerative disorders: a systematic review. - cns neuroscience & therapeutics. 1 - 13.
yuxin shan, hongjian shen, ling huang, hamizah shahirah hamezah, rongchun han, xia ren, chunhong zhang, xiaohui tong. (2025). optimized maxent analysis revealing the change of potential distribution area of lygodium japonicum in china driven by global warming. - frontiers in plant science. 1 - 13.
ahmed mediani, hamizah shahirah hamezah, emelda rosseleena rohani, nurkhalida kamal, vikneswari perumal, fatimah salim, ivana nur allisya rozlan, khaoula hellal, syed mahmood, nabil ali al-mekhlafi. (2023). afzelin: advances on resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology. - . 1-45.
hamizah shahirah hamezah, ummi kalthum azlan, ahmed mediani. (2024). effect of moringa oleifera leaves extract on cognitive function in lipopolysaccharide (lps)-induced rats. - international symposium on science and technology ukm-psu 2024 (isstup2024). 10.
hamizah shahirah binti hamezah;syarul nataqain binti baharum;wan mohd aizat bin wan kamaruddin;ng chyan leong. (2024). elucidating the effect of mitragynine supplementation on brain proteome profiles, cognitive and locomotor functions of lipopolysaccharide-induced neuroinflammation in rats. - . .
hamizah shahirah hamezah. (2024). age-related alterations of brain proteome profiles in aging. - international meeting - 48th annual conference of the msbmb (im-msbmb48). .
hamizah shahirah hamezah, ummi kalthum azlan. (2024). modulation of moringa oleifera on neuroinflammation-induced cognitive impairment in rats. - international conference on natural products 2024 (icnp 2024). .
ummi kalthum azlan, hamizah shahirah hamezah. (2024). the effect of moringa oleifera leaves extract on behavioral changes and proteins modulation in lipopolysaccharide (lps)-induced neuroinflammation rats. - international symposium on synthetic biology and crispr technology (isynbioct 2024). .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| DECIPHERING ANTIDIABETIC EFFECT AND MOLECULAR MECHANISM OF NEPTUNIA OLERACEA PHENOLICS RICH FRACTIONS LOADED IN NANOPARTICLES USING NMR- AND MS-BASED METABOLOMICS. | estika research centre (erc) | 96.6% (2023-10-01 sehingga 2025-09-30) |
| DECIPHERING ANTIDIABETIC EFFECT AND MOLECULAR MECHANISM OF NEPTUNIA OLERACEA PHENOLICS RICH FRACTIONS LOADED IN NANOPARTICLES USING NMR- AND MS-BASED METABOLOMICS. | estika research centre (erc) | 96.6% (2023-10-01 sehingga 2025-09-30) |
| NEUROPROTECTIVE EFFECT OF A CHOCOLATE FORMULATION CONTAINING POLYPHENOL-RICH EXTRACTS OF COCOA AND MORINGA OLEIFERA AGAINST H2O2-INDUCED NEUROTOXICITY IN HUMAN NEUROBLASTOMA SH-SY5Y CELLS | lembaga koko malaysia | 56.3% (2025-02-12 sehingga 2026-02-11) |