Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
Suzana binti Makpol is a Professor of Biochemistry at Faculty of Medicine, Universiti Kebangsaan Malaysia. She graduated from Universiti Kebangsaan Malaysia with Bachelor of Science Hons (Clinical Biochemistry) in 1992 and obtained her PhD (Medical Biochemistry) from the same university in 1997. She then went to Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan in year 2000 for research training and did an attachment at Linus Pauling Institute, Oregon State University, USA in 2008. Professor Makpol has been investigating the molecular changes that occur with ageing and elucidating the molecular mechanisms of natural compounds such as palm tocotrienols, microalgae Chlorella vulgaris, gelam honey, Piper betle and Zingiber officinale Roscoe (ginger) in delaying ageing with emphasis on intracellular signaling pathways and its regulation by genes, transcription factors and micro RNAs. In her studies, she has been using stress-induced premature senescence (SIPS) model of human diploid fibroblasts, replicative senescence model of human diploid fibroblasts, and myoblasts which represent cellular ageing besides the animal model. She has also developed the in vitro model of Alzheimer’s disease carrying the double Swedish/Indiana mutations. She has published more than 100 papers in peer-reviewed international journals and presented more than 150 seminar papers in local and international conferences. She has held many research grants and is currently involved in several research projects.
sophia ogechi ekeuku, siti liyana saud gany, jen kit tan, nur fathiah abdul sani, nur fatin nabilah mohd sahardi, mariam firdhaus mad nordin, suzana makpol. (2026). zingiber officinale roscoe (ginger) extract alleviates age-induced hepatic lipid profile change in rats during ageing. - journal of functional foods. 1 - 14.
nor amira nabila amir razak, jo aan goon, wan zurinah wan ngah, suzana makpol, nor faeizah ibrahim, nur fathiah abdul sani, kok yong chin, amilia aminuddin, mohd heikal mohd yunus, munirah md mansor. (2026). third interim report for a randomized, double-blinded, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol rich fraction (davoslife e3 complete). - . .
noor azleen mohamad, amirah abdul rahman, siti hamimah sheikh abdul kadir, safaa m. naes, musalmah mazlan and suzana makpol. (2026). hydroxychavicol in combination with 5-fluorouracil induced apoptosis by inhibiting purine metabolism in ht-29 and dld-1 cell lines. - chinese journal of integrative medicine. 138 - 146.
anika tabassum , siti liyana saud gany, jen kit tan & suzana makpol. (2026). liver metabolite profiles and oxidative stress in ageing rats and their modulation by tocotrienol-rich fraction (profil metabolit hati dan tekanan oksidatif pada tikus yang semakin tua dan modulasinya oleh fraksi kaya-tokotrienol). - sains malaysiana. 475 - 489.
noradliyanti rusli, jen kit tan, suzana makpol, isma liza mohd isa , nur haleeda hakimi , nazirah ab rani , rabani remli . (2025). exploring the effects of palm tocotrienol-rich fraction in diabetic peripheral neuropathy rat’s model: an untargeted metabolomic profiling and correlation study. - international journal of molecular scinces. 1 - 28.
sophia ogechi ekeuku, siti liyana saud gany, jen kit tan, nur fathiah abdul sani, nur fatin nabilah mohd sahardi, mariam firdhaus mad nordin, suzana makpol. (2026). zingiber officinale roscoe (ginger) extract alleviates age-induced hepatic lipid profile change in rats during ageing. - journal of functional foods. 1 - 14.
noor azleen mohamad, amirah abdul rahman, siti hamimah sheikh abdul kadir, safaa m. naes, musalmah mazlan and suzana makpol. (2026). hydroxychavicol in combination with 5-fluorouracil induced apoptosis by inhibiting purine metabolism in ht-29 and dld-1 cell lines. - chinese journal of integrative medicine. 138 - 146.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
noradliyanti rusli, jen kit tan, suzana makpol, isma liza mohd isa , nur haleeda hakimi , nazirah ab rani , rabani remli . (2025). exploring the effects of palm tocotrienol-rich fraction in diabetic peripheral neuropathy rat’s model: an untargeted metabolomic profiling and correlation study. - international journal of molecular scinces. 1 - 28.
mohammed s. qoms, sok kuan wong, norsyahida mohd fauzi, khairana husain, suzana makpol, jen kit tan. (2025). microalgae-derived peptides targeting lifestyle-related diseases: discovery, mechanisms, structure–activity relationships, and structural modifications. - antioxidants. 1 - 43.
anika tabassum , siti liyana saud gany, jen kit tan & suzana makpol. (2026). liver metabolite profiles and oxidative stress in ageing rats and their modulation by tocotrienol-rich fraction (profil metabolit hati dan tekanan oksidatif pada tikus yang semakin tua dan modulasinya oleh fraksi kaya-tokotrienol). - sains malaysiana. 475 - 489.
nur fatin nabilah mohd sahardi, manishaa priya, suzana makpol, mohamad nasir shafiee. (2025). clinical translation of metabolomics markers in endometrial carcinoma. - journal of obstetrics and gynecology research. 1 - 11.
amnani aminuddin, pei yuen ng, chee onn leong, suzana makpol, eng wee chua. (2024). potential role of heteroplasmic mitochondrial dna mutations in modulating the subtype-specific adaptation of oral squamous cell carcinoma to cisplatin therapy. - discover oncology. 1 - 17.
jen kit tan, sakinah husna abdul razak, nazirah ab rani, nur haleeda hakimi, hanafi ahmad damanhuri, suzana makpol & wan zurinah wan ngah. (2022). effects of age and tocotrienol-rich fraction on mitochondrial respiratory complexes in the hippocampus of rats. - sains malaysiana. 249-259.
yasmin anum mohd yusof, shailah abdullah, nur fatin nabilah mohd sahardi, wan zurinah wan ngah & suzana makpol. (2022). zingiber officinale and piper betle extracts enhanced the chemopreventive effect against colon cancer cells by targeting caspase-mediated apoptosis. - sains malaysiana. 217-237.
anika tabassum , siti liyana saud gany, jen kit tan & suzana makpol. (2026). liver metabolite profiles and oxidative stress in ageing rats and their modulation by tocotrienol-rich fraction (profil metabolit hati dan tekanan oksidatif pada tikus yang semakin tua dan modulasinya oleh fraksi kaya-tokotrienol). - sains malaysiana. 475 - 489.
sophia ogechi ekeuku, siti liyana saud gany, jen kit tan, nur fathiah abdul sani, nur fatin nabilah mohd sahardi, mariam firdhaus mad nordin, suzana makpol. (2026). zingiber officinale roscoe (ginger) extract alleviates age-induced hepatic lipid profile change in rats during ageing. - journal of functional foods. 1 - 14.
noor azleen mohamad, amirah abdul rahman, siti hamimah sheikh abdul kadir, safaa m. naes, musalmah mazlan and suzana makpol. (2026). hydroxychavicol in combination with 5-fluorouracil induced apoptosis by inhibiting purine metabolism in ht-29 and dld-1 cell lines. - chinese journal of integrative medicine. 138 - 146.
noradliyanti rusli, jen kit tan, suzana makpol, isma liza mohd isa , nur haleeda hakimi , nazirah ab rani , rabani remli . (2025). exploring the effects of palm tocotrienol-rich fraction in diabetic peripheral neuropathy rat’s model: an untargeted metabolomic profiling and correlation study. - international journal of molecular scinces. 1 - 28.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
amnani aminuddin, eng wee chua, chee-onn leong, suzana makpol, pei yuen ng. (2021). potential use of a heat shock protein 90 inhibitor, geldanamycin, in combination therapy with cisplatin in oral squamous cell carcinoma. - mspp 34th scientific meeting 2021. 61-62.
yasmin anum mohd yusof, junaidah@maimunah hassan basri, nor ashiken mokti, suhana mohd saad, suhaniza sulaiman, nur sajaratul binti yahya, emey suhana mohd azamai, suzana makpol, wan zurinah wan ngah. (2011). chlorella vulgaris : a miracle plant?. - 4th international conference on modeling, simulation and applied optimization, icmsao 2011. .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
suzana makpol, nur fathiah abdul sani. (2022). pengukuran peroksidasi lipid menggunakan sitometri aliran dengan kaedah pewarnaan pendarfluor c11-bodipy 581/591. - . 50-58.
suzana makpol dan azrina zainal abidin. (2025). tokotrienol kelapa sawit sebagai sebatian anti penuaan: peranannya terhadap telomer dan telomerase sel. - . .
jamia azdina jamal, poh bee koon, salasiah hanin hamjah. (2025). inovasi perubatan dari penemuan ke amalan kesihatan. - . .
norwahidah abdul karim, hazirah hassan, suzana makpol, fazaine zakaria. (2024). mitokondria dan gangguan spektrum autisme: madu kelulut sebagai rawatan alternatif. - . .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
nor amira nabila amir razak, jo aan goon, wan zurinah wan ngah, suzana makpol, nor faeizah ibrahim, nur fathiah abdul sani, kok yong chin, amilia aminuddin, mohd heikal mohd yunus, munirah md mansor. (2026). third interim report for a randomized, double-blinded, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol rich fraction (davoslife e3 complete). - . .
mohd azli, s.n.a., mohd khairul zain, n.h., wan ngah, w.z., goon, j.a., damanhuri, h., abdul karim, n., chin, k.y., tan, j.k., aminuddin, a., md mansor, m., mohd yunus, m.h., ung, y.w., yap, w.n., loong, h.y., abdul sani, f., makpol, s.. (2025). effect of body mass index on bone mineral density in middle-aged adults. - postgraduate research conference 2025 . .
profesor dr suzana makpol, prof. emeritus dato’ dr. wan zurinah wan ngah, assoc. prof. dr. goon jo aan, assoc. prof. dr. hanafi damanhuri, dr. norwahidah abdul karim, assoc. prof. dr. chin kok yong, assoc. prof. dr. tan jen kit, dr. amilia aminuddin, dr. munirah md mansor, dr. mohd heikal mohd yunus, ms ung yee wei, dr yap wei ney, ms marianne loong hsieu yen, puan nur fathiah abdul sani. (2025). third progress report on tocotrienol as a senolytic agent: a phase 2 clinical trial. - . .
siti nor amira mohd azli1, nurul husnina mohd khairul zain, wan zurinah wan ngah, jo aan goon, norwahidah abdul karim, kok yong chin, jen kit tan, amilia aminuddin, munirah md mansor, mohd heikal mohd yunus, yee wei ung, wei ney yap, hsieu yen loong, nur fathiah abdul sani and suzana makpol. (2025). association between body mass index and hemodynamic indicators in normal healthy middle-aged adults . - international palm oil congress and exhibition 2025 . .
jen kit tan, kartthigeen tamel selvan, jo aan goon, suzana makpol. (2025). metabolomics profiling of nafld cells treated with aurantiochytrium sp. hot water extract. - metabolomics 2025. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| ELUCIDATING THE EFFECT OF MITOCHONDRIA FUNCTION ON METABOLOMIC AND LIPIDOMIC CHANGES IN THE LIVER DURING AGEING AND ITS MODULATION BY GINGER EXTRACT | genomax technologies sdn bhd | 83.1% (2025-01-28 sehingga 2026-07-27) |
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | malaysian palm oil board (mpob) | 81.7% (2022-11-29 sehingga 2027-01-30) |
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | davos life science sdn bhd | 81.7% (2022-11-29 sehingga 2027-01-30) |
| ELUCIDATING THE ROLE OF GUT MICROBIOME AND ITS METABOLITES IN ALZHEIMER’S DISEASE AND ITS MODULATION BY TOCOTRIENOLS | sd guthrie research sdn. bhd. | 57.9% (2024-08-01 sehingga 2027-07-31) |
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cellular senescence, Molecular neuroscience, Antioxidants and degenerative diseases, Tocotrienols, Ginger
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Ageing and degenerative diseases
Pengalaman / Experience : 23 tahun/years(s)