Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
Suzana binti Makpol is a Professor of Biochemistry at Faculty of Medicine, Universiti Kebangsaan Malaysia. She graduated from Universiti Kebangsaan Malaysia with Bachelor of Science Hons (Clinical Biochemistry) in 1992 and obtained her PhD (Medical Biochemistry) from the same university in 1997. She then went to Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan in year 2000 for research training and did an attachment at Linus Pauling Institute, Oregon State University, USA in 2008. Professor Makpol has been investigating the molecular changes that occur with ageing and elucidating the molecular mechanisms of natural compounds such as palm tocotrienols, microalgae Chlorella vulgaris, gelam honey, Piper betle and Zingiber officinale Roscoe (ginger) in delaying ageing with emphasis on intracellular signaling pathways and its regulation by genes, transcription factors and micro RNAs. In her studies, she has been using stress-induced premature senescence (SIPS) model of human diploid fibroblasts, replicative senescence model of human diploid fibroblasts, and myoblasts which represent cellular ageing besides the animal model. She has also developed the in vitro model of Alzheimer’s disease carrying the double Swedish/Indiana mutations. She has published more than 100 papers in peer-reviewed international journals and presented more than 150 seminar papers in local and international conferences. She has held many research grants and is currently involved in several research projects.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
anika tabassum, siti liyana saud gany, jen kit tan, suzana makpol. (2025). untargeted liver metabolites profiling and oxidative stress and inflammatory markers expression in sprague dawley rats supplemented with palm tocotrienol-rich fraction and its effect on hepatic changes during ageing. - 5th international conference on advances in medical science 2025. .
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
sophia ogechi ekeuku, nurhazirah zainul azlan, yasmin anum mohd yusof, jen kit tan, suzana makpol. (2024). unveiling the impact of chlorella vulgaris supplementation on liver metabolisms of aged rats - a preclinical study. - journal of functional foods. 1 - 7.
nur fatin nabilah mohd sahardi, manishaa priya, suzana makpol, mohamad nasir shafiee. (2025). clinical translation of metabolomics markers in endometrial carcinoma. - journal of obstetrics and gynecology research. 1 - 11.
amnani aminuddin, pei yuen ng, chee onn leong, suzana makpol, eng wee chua. (2024). potential role of heteroplasmic mitochondrial dna mutations in modulating the subtype-specific adaptation of oral squamous cell carcinoma to cisplatin therapy. - discover oncology. 1 - 17.
sheng zhang lim, raja affendi raja adli, suzana makpol & eng wee chua. (2022). therapeutic monitoring of thiopurine metabolites: validation of an hplc method and preliminary findings from a small cohort of malaysian patients with inflammatory bowel disease. - sains malaysiana. 1847-1859.
khaizurin tajul arifin, noor ikhwan shansuddin, norwahidah abdul karim & suzana makpol. (2022). hot water extract from saccharomyces cerevisiae scavenges dpph and reduces senescence associated b-galactosidase (sa-b-gal) in human dermal fibroblasts. - sains malaysiana. 2415-2424.
jen kit tan, sakinah husna abdul razak, nazirah ab rani, nur haleeda hakimi, hanafi ahmad damanhuri, suzana makpol & wan zurinah wan ngah. (2022). effects of age and tocotrienol-rich fraction on mitochondrial respiratory complexes in the hippocampus of rats. - sains malaysiana. 249-259.
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
nor amira nabila amir razak, jo aan goon, wan zurinah wan ngah, suzana makpol, mohd hanafi ahmad damanhuri, nor faeizah ibrahim, nur fathiah abdul sani, nuraqila mohd murshid, anis faqihah mohd azizan, kok yong chin, amilia aminuddin, mohd heikal mohd yunus, munirah md mansor , juvenia rui en neo, wei ney yap, hsieu yen loong, yee wei ung. (2025). effectiveness of tocotrienol-rich fraction in older adults: protocol for a randomized, double-blind, placebo-controlled trial. - jmir research protocols. 1 - 18.
amnani aminuddin, eng wee chua, chee-onn leong, suzana makpol, pei yuen ng. (2021). potential use of a heat shock protein 90 inhibitor, geldanamycin, in combination therapy with cisplatin in oral squamous cell carcinoma. - mspp 34th scientific meeting 2021. 61-62.
yasmin anum mohd yusof, junaidah@maimunah hassan basri, nor ashiken mokti, suhana mohd saad, suhaniza sulaiman, nur sajaratul binti yahya, emey suhana mohd azamai, suzana makpol, wan zurinah wan ngah. (2011). chlorella vulgaris : a miracle plant?. - 4th international conference on modeling, simulation and applied optimization, icmsao 2011. .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
suzana makpol, nur fathiah abdul sani. (2022). pengukuran peroksidasi lipid menggunakan sitometri aliran dengan kaedah pewarnaan pendarfluor c11-bodipy 581/591. - . 50-58.
norwahidah abdul karim, hazirah hassan, suzana makpol, fazaine zakaria. (2024). mitokondria dan gangguan spektrum autisme: madu kelulut sebagai rawatan alternatif. - . .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
suzana makpol. (2022). produk semulajadi: halia dalam kesihatan. - impak. 31.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
suzana makpol, nur fathiah abdul sani. (2022). pengukuran peroksidasi lipid menggunakan sitometri aliran dengan kaedah pewarnaan pendarfluor c11-bodipy 581/591. - . 50-58.
rizwana jahan jawahar ali, shairah abdul razak, noor akmal shareela ismail, suzana makpol. (2025). elucidating the changes in the gut microbiome with ageing and its modulation by ginger extract. - postgraduate research conference 2025. .
rizwana jahan jawahar ali & profesor dr suzana makpol. (2025). modulation of ginger extract on gut microbiome changes due to ageing. - international conference of biochemistry, molecular biology & laboratory medicine 2025 icbmblm 2025. .
mohd khairul zain nh, mohd azli sna, makpol s, wan ngah wz, goon ja, damanhuri h, abdul karim n, chin ky, tan jk, aminuddin a, md mansor m, mohd yunus mh, ung yw, yap wn, loong mhy, abdul sani nf. (2025). effects of tocotrienol-rich fraction on dietary intake and body composition: interim findings from a double-blind randomised controlled trial. - 27th medical & health research week 'upholding credibility in an evolving research landscape'. .
goon jo aan, amira nabila amir razak, suzana makpol, nor faeizah ibrahim, nur fathiah sani, amilia aminuddin, mohd heikal mohd yunus, chin kok yong, munirah mansor, wan zurinah wan ngah. (2025). second interim report for clinical trial: a randomized, double-blinded, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol rich fraction (davoslife e3 complete). - . .
anika tabassum, siti liyana saud gany, jen kit tan, suzana makpol. (2025). untargeted liver metabolites profiling and oxidative stress and inflammatory markers expression in sprague dawley rats supplemented with palm tocotrienol-rich fraction and its effect on hepatic changes during ageing. - 5th international conference on advances in medical science 2025. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | malaysian palm oil board | 68.9% (2022-11-29 sehingga 2027-01-30) |
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | davos life science sdn bhd | 68.9% (2022-11-29 sehingga 2027-01-30) |
| RELATIONSHIP BETWEEN GUT AND NASAL MICROBIOME PROFILES WITH T-HELPER PATHWAYS IN PERSISTENT MODERATE-SEVERE ALLERGIC RHINITIS CHILDREN WITH VITAMIN D SUPPLEMENTATION | pharma nord sdn bhd | 88.9% (2023-07-24 sehingga 2026-01-23) |
| EXPLORING NEURONAL EXPANSION BY PHOENIXIN IN PARKINSON`S DISEASE IN VITRO MODEL | monash university | 81.6% (2023-10-01 sehingga 2026-03-31) |
| ELUCIDATING THE EFFECT OF MITOCHONDRIA FUNCTION ON METABOLOMIC AND LIPIDOMIC CHANGES IN THE LIVER DURING AGEING AND ITS MODULATION BY GINGER EXTRACT | genomax technologies sdn bhd | 71.2% (2025-01-28 sehingga 2026-01-27) |
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cellular senescence, Molecular neuroscience, Antioxidants and degenerative diseases, Tocotrienols, Ginger
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Ageing and degenerative diseases
Pengalaman / Experience : 23 tahun/years(s)