pensyarah farmasi
pejabat dekan fakulti farmasi
azrina.azmi@ukm.edu.my
Biografi/ Biography :
Makmal kami menyelidik kesan pelbagai sebatian psikoaktif dan fitokimia pada fungsi otak. Kajian makmal ditumpukan pada menggunakan pendekatan pelbagai seperti ujian tingkah laku haiwan dan ujian in vitro untuk mendedahkan pandangan kritikal kepada tiga bidang asas: Penilaian Ketoksikan dan Perlindungan Saraf; Mekanisme Neurotoksisiti dan Perlindungan Saraf; Kesan Kognitif, Tingkah Laku Pengukuhan Positif dan Tingkah Laku Penarikan.
Tumpuan utama penyelidikan kami ialah pada bidang produk semula jadi yang berasal daripada tumbuhan, yang mempunyai potensi dalam mencegah kemerosotan saraf. Kami menyelidiki secara mendalam mekanisme sebatian ini dalam memberikan perlindungan saraf, dengan mengambil kira potensinya sebagai suplemen untuk mengekalkan kesihatan otak secara keseluruhan.
Sebagai tindak balas kepada cabaran yang timbul akibat percambahan Bahan Psikoaktif Baharu (NPS), usaha penyelidikan kami telah berkembang untuk merangkumi kajian sebatian sintetik ini. Melalui ujian tingkah laku haiwan yang komprehensif, kesan buruk NPS pada sistem saraf pusat dan potensi risikonya kepada kesihatan manusia akan diselidik.
Melalui pendekatan interdisiplin dan komitmen kami kepada kajian saintifik, pemahaman tentang fungsi otak akan dikembangkan bagi menyumbang kepada pembangunan strategi untuk melindungi kesihatan otak dalam menghadapi cabaran berkaitan kesihatan manusia sejagat.
In our laboratory, we are deeply engaged in cutting-edge research that delves into the intricate effects of various psychoactive and phytochemical compounds on brain functions. Our focus lies in employing a multifaceted approach, utilizing animal behavioral tests and in vitro assays, to uncover critical insights into three fundamental areas: Neurotoxicity and Neuroprotection Assessment, Mechanisms of Neurotoxicity and Neuroprotection; Cognitive Effects, Positive Reinforcement and Withdrawing Behaviour.
A primary focus of our investigations lies in the realm of plant-derived natural products, which hold immense promise in preventing neurodegeneration. We delve deep into the mechanisms through which these compounds confer neuroprotection, with an eye toward their potential as supplements for promoting overall brain wellness.
In response to the emerging challenge posed by the proliferation of New Psychoactive Substances (NPS), our research endeavours have expanded to encompass the study of these synthetic compounds. Through a comprehensive battery of animal behavioural tests, we seek to elucidate the profound effects of NPS on the central nervous system, striving to unveil the potential health risks they pose to human well-being.
Through our interdisciplinary approach and unwavering commitment to scientific inquiry, we aim to advance our understanding of brain function and contribute to the development of strategies for safeguarding neurological health in the face of evolving challenges.
mohammad yusuf hasan, azim haikal md roslan, norazrina azmi, norlinah mohamed ibrahim, alina arulsamy, vanessa lin lin lee, rosfaiizah siran, sharmili vidyadaran, eng wee chua, mohd kaisan mahadi. (2025). a7-nicotinic acetylcholine receptor activation modulates bv2 microglial plasticity via mir-21/tnf-a/nfkb in oxygen-glucose deprivation/reoxygenation. - journal of molecular neuroscience. 1 - 13.
mohd khairulanwar bunaim, hanafi ahmad damanhuri, hui-yin yow, nor syafinaz yaakob, mohd makmor-bakry, norazrina azmi. (2024). understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. - international journal of legal medicine. 1-12.
jamia azdina jamal, rosnani hashim, mohd makmor bakry, siti hadijah shamsudin, nor amlizan ramli, sujatha d/o suthandiram, mohd ishak mohd hussaini, nurulfajar mohd jamid, mohammad hafiz othman, hanisah shafie. (2024). standards for undergraduate pharmacy programme 2024. - . .
poh kuan wong, norazrina azmi, saiful effendi syafruddin, fook choe cheah, eng wee chua. (2024). rna sequencing reveals transcriptomic changes in hek293 cells following introduction of rs16851030 dna variant. - malaysian journal of medicine and health sciences. 49.
nor syafinaz yaakob, liyana shafiqah sahul hamid, fadhlullah zuhair japar sidik, norazrina azmi, juriyati jalil, eng wee chua. (2024). the anti-addictive potential of 6-gingerol and 6-gingerol standardised zingiber officinale extract in nicotine addiction mouse model. - 10th international conference on traditional and complementary medicine (intracom). .
mohammad yusuf hasan, azim haikal md roslan, norazrina azmi, norlinah mohamed ibrahim, alina arulsamy, vanessa lin lin lee, rosfaiizah siran, sharmili vidyadaran, eng wee chua, mohd kaisan mahadi. (2025). a7-nicotinic acetylcholine receptor activation modulates bv2 microglial plasticity via mir-21/tnf-a/nfkb in oxygen-glucose deprivation/reoxygenation. - journal of molecular neuroscience. 1 - 13.
mohd khairulanwar bunaim, hanafi ahmad damanhuri, hui-yin yow, nor syafinaz yaakob, mohd makmor-bakry, norazrina azmi. (2024). understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. - international journal of legal medicine. 1-12.
poh kuan wong, nurul nadia mohamad zamberi, saiful effendi syafruddin, fook choe cheah, norazrina azmi, jia xian law, eng wee chua. (2023). the promises and pitfalls of crispr-mediated base editing in stem cells. - crispr journal. 196-215.
affidah sabran, endang kumolosasi, ibrahim jantan, jamia azdina jamal, norazrina azmi, malina jasamai. (2021). induction of cell death and modulation of annexin a1 by phytoestrogens in human leukemic cell lines. - saudi pharmaceutical journal. 73-84.
poh kuan wong, fook choe cheah, saiful effendi syafruddin, m aiman mohtar, norazrina azmi, pei yuen ng, eng wee chua. (2021). crispr gene-editing models geared toward therapy for hereditary and developmental neurological disorders. - frontiers in pediatrics. 1-15.
poh kuan wong, saiful effendi syafruddin, fook choe cheah, norazrina azmi, pei yuen ng, eng wee chua. (2024). introduction of a single-nucleotide variant, rs16851030, into the adora1 gene increased cellular susceptibility to hypoxia. - personalized medicine. 353 - 366.
nor syafinaz yaakob, mohamed ali seyed, manali haniti mohd-zahid, heng-hui tee, shu-yun yap, sek-wen ho, yusof kamisah, norazrina azmi. (2023). neuroprotective effects of ocimum basilicum l. var. thyrsiflora on scopolamine-induced non-spatial memory deficits in rats. - sains malaysiana. 837-850.
raajeswari satiamurthy, nor syafinaz yaakob, noraida mohamed shah, norazrina azmi, marhanis salihah omar. (2023). potential roles of 5-ht3 receptor antagonists in reducing chemotherapy-induced peripheral neuropathy (cipn). - current molecular medicine. 341-349.
lok mun law, norazrina azmi, ian charles paterson, pei yuen ng. (2022). p2y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis. - sains malaysiana. 175-186.
sanggavi nadarajan, norazrina azmi, malina jasamai, endang kumolosasi. (2021). annexin a1 (anxa1): a systematic review of its role in inflammation. - sains malaysiana. 207-226.
mohammad yusuf hasan, azim haikal md roslan, norazrina azmi, norlinah mohamed ibrahim, alina arulsamy, vanessa lin lin lee, rosfaiizah siran, sharmili vidyadaran, eng wee chua, mohd kaisan mahadi. (2025). a7-nicotinic acetylcholine receptor activation modulates bv2 microglial plasticity via mir-21/tnf-a/nfkb in oxygen-glucose deprivation/reoxygenation. - journal of molecular neuroscience. 1 - 13.
poh kuan wong, norazrina azmi, saiful effendi syafruddin, fook choe cheah, eng wee chua. (2024). rna sequencing reveals transcriptomic changes in hek293 cells following introduction of rs16851030 dna variant. - malaysian journal of medicine and health sciences. 49.
mohd khairulanwar bunaim, hanafi ahmad damanhuri, hui-yin yow, nor syafinaz yaakob, mohd makmor-bakry, norazrina azmi. (2024). understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. - international journal of legal medicine. 1-12.
poh kuan wong, saiful effendi syafruddin, fook choe cheah, norazrina azmi, pei yuen ng, eng wee chua. (2024). introduction of a single-nucleotide variant, rs16851030, into the adora1 gene increased cellular susceptibility to hypoxia. - personalized medicine. 353 - 366.
bayu eko prasetyo, norazrina azmi, lia laila, ahmad fuad shamsuddin. (2023). propofol quantification method in palm oil based nanoemulsion formula using rp-hplc. - research journal of pharmacy and technology. 2622-2626.
adliah mhd ali, tee pey chiau, thomas paraidathathu, mohd makmor bakry, nur akmar taha, shariza sahudin, norazrina azmi, endang kumolosasi, siti azdiah abdul aziz. (2012). the effectiveness of feedback using video recording as a potential teaching method in communication and counselling among pharmacy students. - procedia social and behavioral sciences. .
thomas paraidathathu, jamia azdina jamal, norazrina azmi. (2011). preceptor assessment of the competencies of pharmacy graduates. - kongres pengajaran dan pembelajaran ukm, 2010; tanjung keling, melaka (procedia social and behavioral sciences). .
jamia azdina jamal, thomas paraidathathu, norazrina azmi. (2011). knowledge and attitudes of pharmacy students regarding traditional medicine. - kongres pengajaran dan pembelajaran ukm, 2010; tanjung keling, melaka (procedia social and behavioral sciences). .
endang kumolosasi, malina jasamai, norazrina azmi. (2023). sistem imun dan tumbuhan ubatan sebagai agen immunomodulasi. - . 11-31.
norazrina azmi, sharmilla elangovan, chua eng wee, ibrahim jantan. (2023). dukung anak (phyllanthus amarus). - . 47-59.
endang kumolosasi, malina jasamai, norazrina azmi. (2023). sistem imun dan tumbuhan ubatan sebagai agen immunomodulasi. - . 11-31.
endang kumolosasi, malina jasamai, norazrina azmi. (2023). tumbuhan herba terpilih: berpotensi sebagai agen immunomodulatori. - . 176.
norazrina azmi. (2023). rangka kerjasama bersepadu kawal penggunaan dadah sintetik. - berita harian. 1.
norazrina azmi. (2023). selamat pagi malaysia dan berita rtm. - dadah sintetik: rangka kerjasama bersepadu tangani isu. .
norazrina azmi, sharmilla elangovan, chua eng wee, ibrahim jantan. (2023). dukung anak (phyllanthus amarus). - . 47-59.
jamia azdina jamal, rosnani hashim, mohd makmor bakry, siti hadijah shamsudin, nor amlizan ramli, sujatha d/o suthandiram, mohd ishak mohd hussaini, nurulfajar mohd jamid, mohammad hafiz othman, hanisah shafie. (2024). standards for undergraduate pharmacy programme 2024. - . .
nor syafinaz yaakob, liyana shafiqah sahul hamid, fadhlullah zuhair japar sidik, norazrina azmi, juriyati jalil, eng wee chua. (2024). the anti-addictive potential of 6-gingerol and 6-gingerol standardised zingiber officinale extract in nicotine addiction mouse model. - 10th international conference on traditional and complementary medicine (intracom). .
nor syafinaz yaakob, raajeswari satiamurthy, norazrina azmi, che aishah nazariah ismail, noraida mohamed shah . (2024). antinociceptive effects of 5-ht3 receptor antagonists on a chemotherapy-induced peripheral neuropathy rat model . - 3rd macr international scientific conference (3rd msc). .
norazrina azmi. (2023). selamat pagi malaysia dan berita rtm. - dadah sintetik: rangka kerjasama bersepadu tangani isu. .
liyana shafiqah sahul hamid, norazrina azmi, juriyati jalil, chua eng wee, satirah zainalabidin, nor syafinaz yaakob. (2023). investigating the effects of 6-gingerol and 6-gingerol standardized zingiber officinale extract on chronic nicotine addiction in mice. - monash international health science and technology conference (initiate) 2023. 102.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| KESAN KETAGIHAN DAN KETOKSIKAN BAHAN PSIKOAKTIF BAHARU (NPS) TERPILIH | jabatan siasatan jenayah narkotik, polis diraja malaysia | 57.9% (2023-11-01 sehingga 2026-12-31) |
| EFFECTS OF PALM TOCOTRIENOLS IN MODULATING THE SEX HORMONE PRODUCTIONS IN THE ADRENAL GLANDS AND ITS BONE PROTECTIVE EFFECTS IN OVARIECTOMISED RATS | excelvite sdn. bhd | 85.2% (2023-10-01 sehingga 2025-12-31) |
| IN VIVO SCREENING AND IDENTIFICATION OF POTENTIAL STANDARDISED PLANT EXTRACTS WITH RELAXATION OR ENERGIZING EFFECT | delightex pte ltd | 88.2% (2023-03-01 sehingga 2025-12-31) |
| PEMBANGUNAN PROSEDUR PENGENALPASTIAN DAN PENCIRIAN BAGI PENJEJAKAN FORENSIK ASAL USUL DADAH NPS | jabatan siasatan jenayah narkotik, polis diraja malaysia | 55.5% (2024-01-01 sehingga 2026-12-31) |
| PROFILING THE PATTERN OF USE OF NEW PSYCHOACTIVE SUBSTANCES (NPS) IN MALAYSIA | agensi anti dadah kebangsaan | 86.3% (2024-05-15 sehingga 2025-11-14) |
| UNRAVELING THE CHANGES IN PREFRONTAL CORTEX TRANSCRIPTOME IN ACUTE METHAMPHETAMINE WITHDRAWAL-MEDIATED COGNITIVE IMPAIRMENTS IN MALE AND FEMALE RATS. | solace asia sdn bhd | 86.3%(2024-11-01 sehingga 2026-10-31) |
| REPURPOSING EMPAGLIFLOZIN: MITOCHONDRIAL RESCUE AND ROS REDUCTION IN STROKE REPERFUSION INJURY | neo nexon sdn bhd | 86.3%(2024-11-01 sehingga 2026-10-31) |