pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
effendisy@ppukm.ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
Saiful Effendi Syafruddin is a Research Fellow/Senior Lecturer at the UKM Medical Molecular Biology Institute (UMBI). He holds PhD in Medical Sciences from the University of Cambridge, UK. He previously earned his Master’s in Biotechnology (Molecular Genetic) from the University of Pennsylvania, USA, and BSc. in Biotechnology from Rochester Institute of Technology, USA. His PhD project focused on elucidating the genetic and epigenetic determinants that support kidney cancer pathogenesis. Saiful Effendi research interest revolves around understanding cancer molecular dependencies, specifically in kidney cancer, with the aim to identify novel and efficient clinical strategies to fight against cancer. Having been trained in the field of cell and molecular biology, cancer biology and genetic engineering for more than a decade, he has been extensively utilizing various state-of-the-art laboratory techniques throughout his cancer research works. Several of his research works have been published in high impact journals such as Nature, Cancer Discovery, Nature Communication, and Cell.
nur qurratu’ athirah a rahman, norfarhana mazlan, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin. (2025). transcriptomic profiling of dual hif2a and klf6 repression reveals a co-regulatory network driving ccrcc progression. - aacr on campus malaysia 2025. .
nurul iffah mohd isa, saiful effendi syafruddin, shahidee zainal abidin, mohd faizal ahmad, mohd helmy mokhtar, azizah ugusman, adila a hamid. (2025). the role of mir-196a-5p in regulating inflammation-related genes in human umbilical vein endothelial cells exposed to hypertensive pregnancy. - the 8th global public health conference . .
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shamsul azhar shah, nao suzuki, abdul kadir abdul karim. (2025). comparison of cumulus cells preparation among diminished ovarian reserved and normal ovarian reserved women for rna extraction and review of literature. - medicine & health. 525 - 545.
yuh cai chia, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart, m. aiman mohtar,. (2025). identification of upstream regulatory elements governing agr2 expression in er+ breast cancer. - crispr 2025 new zealand. .
nurul iffah mohd isa, aslah nabilah abdull sukor, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, mohd helmy mokhtar, azizah ugusman, adila a. hamid. (2025). rna sequencing-based profiling of differentially expressed micrornas in endothelial cells from offspring of hypertensive pregnancies: a preliminary study. - frontiers in molecular biosciences. 1 - 17.
mohd faizal ahmad, nurul yaqin mohd nor, mohammad mahmoud mohammad ramadneh, nurul izyani roseli, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shah shamsul azhar, nao suzuki, abdul kadir abdul karim . (2025). comparative analysis of rescue-in vitro-maturation (r-ivm) outcomes in women with diminished ovarian reserve (dor) versus normal ovarian reserve (nor). - biomedicines. 1 - 13.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shah shamsul azhar, nao suzuki, abdul kadir abdul karim . (2025). a comparative analysis of gremlin-1 (grem1), hyaluronic acid synthetase-2 (has2), and prostaglandin-endoperoxide synthase-2 (ptgs2) expression in cumulus cells among women with diminished ovarian reserve following rescue in vitro maturation (r-ivm). - life. 1 - 25.
suha azizan, kim jun cheng, elsa haniffah mejia mohamed, kamariah ibrahim, farid nazer faruqu, kumutha malar vellasamy, tak loon khong , saiful effendi syafruddin, zaridatul aini ibrahim. (2024). insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (emt) in colorectal cancer: a systematic review and bioinformatic analysis of gene expression. - gene. 1-14.
muhammad bani yamin, fazleen haslinda mohd hatta , mohd shafiq aazmi, saiful effendi syafruddin, michelle yee shuen lee, nurul hanis ramzi ,nikman adli nor hashim and nazia abdul majid. (2025). unravelling putative ethnic-specific obesity genetic loci in malaysian youths: a genome-wide association study. - southeast asian journal of tropical medicine and public health. 253 - 290.
poh kuan wong, saiful effendi syafruddin, fook choe cheah, norazrina azmi, pei yuen ng, eng wee chua. (2024). introduction of a single-nucleotide variant, rs16851030, into the adora1 gene increased cellular susceptibility to hypoxia. - personalized medicine. 353 - 366.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, nao suzuki, shamsul azhar shah, abdul kadir abdul karim. (2024). gene expression profiling of hyaluronic acid synthetase 2 (has2), prostaglandin-endoperoxide synthase 2 (ptgs2) and gremlin 1 (grem1) in cumulus cells among women with diminished ovarian reserved (dor). - mjm vol 79 supplement 3, july 2024 . 7 - 7.
kelly xue jing jong, elsa haniffah mejia mohamed, saiful effendi syafruddin, farid nazer faruqu, kumutha malar vellasamy, kamariah ibrahim, zaridatul aini ibrahim. (2024). il-8 and pi3k pathway influence the susceptibility of trail-sensitive colorectal cancer cells to trail-induced cell death. - molecular biology reports. 1 - 10.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
muhammad bani yamin, fazleen haslinda mohd hatta , mohd shafiq aazmi, saiful effendi syafruddin, michelle yee shuen lee, nurul hanis ramzi ,nikman adli nor hashim and nazia abdul majid. (2025). unravelling putative ethnic-specific obesity genetic loci in malaysian youths: a genome-wide association study. - southeast asian journal of tropical medicine and public health. 253 - 290.
nurul iffah mohd isa, aslah nabilah abdull sukor, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, mohd helmy mokhtar, azizah ugusman, adila a. hamid. (2025). rna sequencing-based profiling of differentially expressed micrornas in endothelial cells from offspring of hypertensive pregnancies: a preliminary study. - frontiers in molecular biosciences. 1 - 17.
nurul nadia mohamad zamberi, siti nur hasanah mohd yusufb m. aiman mohtar, saiful effendi syafruddin. (2025). uncovering the transcription factor network driving klf6 expression through super enhancers in renal cell carcinoma. - asian pacific journal of molecular biology and biotechnology. 17 - 17.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, shah shamsul azhar, nao suzuki, abdul kadir abdul karim . (2025). a comparative analysis of gremlin-1 (grem1), hyaluronic acid synthetase-2 (has2), and prostaglandin-endoperoxide synthase-2 (ptgs2) expression in cumulus cells among women with diminished ovarian reserve following rescue in vitro maturation (r-ivm). - life. 1 - 25.
muhammad-redha abdullah-zawawi, shing cheng tan, m. aiman mohtar, saiful effendi syafruddin, teck yew low, muhammad irfan abdul jalal. (2025). unveiling cancer complexity: machine learning insights into multi-omics data. - . 51 - 69.
aminah suhaila haron, saiful e. syafruddin, ilie fadzilah hashim, muggunna balasubramaniam, saw keat chuan, yasmin hasnizan, nurul syafawani fizal, chong chien fung, ana masara ahmad mokhtar. (2023). genetic mutations and clinical diagnoses associated with increased risk of malignancy in primary immunodeficiencies. - . 235-251.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
azizan baharuddin, noor munirah isa, rofina yasmin othman, nurzatil sharleeza mat jalaluddin, mohd salim mohamed, abdul halim ibrahim, suzana ariff azizan, mohammad firdaus abdul aziz, angelina patrick olesen, nurmadihah takhor, nazlina ibrahim, d ravichandran a/l k dhakshinamoorthy, ahmad fidhaus arham, saiful effendi syafruddin. (2025). garis panduan etika bioteknologi. - . .
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). penyahkawalseliaan proses transkripsi dalam patogenesis kanser. - majalah dewan kosmik. 50-53.
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
nor azian abdul murad, nor azila muhammad azami, saiful effendi syafruddin, & razinah sharif. (2022). corona id 1.0 - pemerkasaan literasi kesihatan terhadap pelajar sekolah semasa era pandemik covid19. - knovasi kongres dan pertandingan inovasi dalam pengajaran dan pembelajaran. 1.
nurul iffah mohd isa, saiful effendi syafruddin, shahidee zainal abidin, mohd faizal ahmad, mohd helmy mokhtar, azizah ugusman, adila a hamid. (2025). the role of mir-196a-5p in regulating inflammation-related genes in human umbilical vein endothelial cells exposed to hypertensive pregnancy. - the 8th global public health conference . .
norfarhana mazlan, saiful effendi syafruddin, mohd khairul nizam mohd khalid, mohamad aimanuddin mohtar, yuslina mat yusoff. (2025). integrated epigenomic and transcriptomic profiling reveals cell cycle dysregulation in cytogenetically normal acute myeloid leukaemia. - aacr on campus malaysia 2025. .
nur qurratu’ athirah a rahman, norfarhana mazlan, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin. (2025). transcriptomic profiling of dual hif2a and klf6 repression reveals a co-regulatory network driving ccrcc progression. - aacr on campus malaysia 2025. .
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
adila a hamid, nurul iffah mohd isa, saiful effendi syafruddin, amilia aminuddin, shahidee zainal abidin, mohd faizal ahmad, azizah ugusman. (2025). profiling of upregulated mirnas in endothelial cells exposed to hypertensive disorders of pregnancy: a bioinformatic analysis . - 38th scientific meeting of the malaysian society of pharmacology . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| INVESTIGATING ENGINEERED NANOVESICLE CAPTURING AGENT AGAINST PRO-ANGIOGENIC VEGFA IN RENAL CARCINOMA | genscript biotech (singapore) private limited | 76.6% (2025-03-03 sehingga 2026-03-02) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | nanoarms sdn. bhd. | 87.5% (2023-10-01 sehingga 2026-03-31) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | genomax technologies sdn bhd | 87.5% (2023-10-01 sehingga 2026-03-31) |
BIOLOGY :PURE AND APPLIED SCIENCES
Cellular and Molecular Biology, Genomics, Genetic Engineering
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cancer Biology
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cancer Genetic and Epigenetic
Pengalaman / Experience : 8 tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Recombinant DNA technology and gene targeting
Pengalaman / Experience : 10 tahun/years(s)
MEDICAL MOLECULAR BIOLOGY :BASIC MEDICAL SCIENCES
CRISPR Technology, Gene Editing, Genome Engineering
Pengalaman / Experience : 10 tahun/years(s)