pensyarah universiti
jabatan kejuruteraan tisu & perubatan regeneratif
dain@ukm.edu.my
Biografi/ Biography :
Comprehensive knowledge of signaling molecules and the expression trends of numerous molecular regulators play a crucial role in orchestrating appropriate cellular responses, such as cytoskeletal changes, cell growth and division, matrix synthesis and degradation, differentiation, cell senescence, and apoptosis. This understanding is essential for maintaining cellular equilibrium and is of paramount importance in the development of novel therapeutic targets by exploring how cells communicate with each other and how cell signaling pathways are implicated in the pathophysiology of diseases.
Currently, scientific research is focused on unraveling the mechanisms of action and consequences of specific protein expression modifications, enabling the potential for targeted manipulation in therapeutic interventions. Stem cells and their derivatives, known as secretomics, offer an extensive reservoir of signaling molecules that captivates the scientific community, yet their functions remain incompletely understood. Harnessing the potential of stem cells has paved the way for personalized medicine, making therapeutic approaches tailored to individual patients achievable.
Hence, it becomes crucial to comprehend the specific signaling pathways involved in the pathophysiology of various diseases, including rare conditions like Duchenne Muscular Dystrophy and Vagina Agenesis, as well as non-communicable diseases such as Cardiovascular and Neurodegenerative disorders. Understanding these pathways is essential before introducing any compound, protein, or drug for treatment, as it ensures the safety and efficacy of proposed therapeutic approaches.
By focusing on these fundamental principles of cellular communication and signaling, researchers can uncover new avenues for therapeutic development and advancements in the field of medicine, ultimately improving the lives of patients suffering from a wide range of diseases.
anam anjum, muhammad dain yazid, muhammad fauzi daud, jalilah idris, angela min hwei ng, amaramalar selvi naicker, ohnmar htwe ismail, ramesh kumar athi kumar, yogeswaran lokanathan. (2025). neuroaid™-ii (mlc901) provides neuroprotection and enhances neuronal cell survival against kainic acid-induced excitotoxicity in vitro by activating the pi3k/akt pathway. - future journal of pharmaceutical sciences. 1 - 12.
muhammad najib fathi hassan, muhammad dain yazid, mohd heikal bin mohd yunus, yogeswaran lokanathan, min hwei ng, ruszymah bt hj idrus, yee loong tang, see nguan ng, jia xian law. (2025). comparing the growth kinetics and characteristics of wharton’s jelly derived mesenchymal stem cells expanded using different culture mediums. - cytotechnology. 1 - 16.
roa m. a. aliwaisi, intan zarina zainol abidin, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). cytotoxicity and in vitro osteogenic differentiation potential of alpha-asarone on mc3t3-e1 cells. - the 5th international conference on advances in medical sciences. 38 - 38.
intan zarina zainol abidin, roa m.a. aliwaisi, zulham yamamoto, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). osteogenic potential in piper sarmentosum roxb.: a systematic review of in vitro and in vivo evidence. - sains malaysiana. 1875 - 1887.
duangjai tungmunnithum, yohei sasaki, aekkhaluck intharuksa. (2025). effects of hydroxytyrosol in endothelial functioning: a comprehensive review. - special issue reprint. 66 - 84.
adiba najwa muzammil, muttiah barathan, muhammad dain yazid, nadiah sulaiman, suzana makpol, norlinah mohamed ibrahim, faizul jaafar, nur atiqah haizum abdullah. (2024). a systematic scoping review of the multifaceted role of phoenixin in metabolism: insights from in vitro and in vivo studies. - frontiers in endocrinology. 1 - 22.
anam anjum, muhammad dain yazid, muhammad fauzi daud, jalilah idris, angela min hwei ng, amaramalar selvi naicker, ohnmar htwe rashidah ismail, ramesh kumar athi kumar, yogeswaran lokanathan. (2024). neuroaidtm-ii (mlc901) promoted neurogenesis by activating the pi3k/akt/gsk-3ß signaling pathway in rat spinal cord injury models. - biomedicines. 1 - 21.
nur a’tiqah haron, mohamad fikeri ishak, muhammad dain yazid, ubashini vijakumaran, roszita ibrahim, raja zahratul azma raja sabudin, hafiza alauddin, nur ayub md ali, hairulfaizi haron, muhammad ishamuddin ismail, mohd ramzisham abdul rahman and nadiah sulaiman. (2024). exploring the potential of saphenous vein grafts ex vivo: a model for intimal hyperplasia and re-endothelialization. - journal of clinical medicine. 1 - 17.
shahrul hisham zainal ariffin, rohaya megat abdul wahab, muhammad abdul razak, muhammad dain yazid, muhammad ashraf shahidan, azizi miskon, intan zarina zainol abidin. (2024). evaluation of in vitro osteoblast and osteoclast differentiation from stem cell: a systematic review of morphological assays and staining techniques. - peerj. 1 - 22.
yi ting lee, mohd heikal mohd yunus, muhammad dain yazid and azizah ugusman. (2024). unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic intervention. - frontiers in cell and developmental biology. 1-16.
muhammad najib fathi hassan, muhammad dain yazid, mohd heikal bin mohd yunus, yogeswaran lokanathan, min hwei ng, ruszymah bt hj idrus, yee loong tang, see nguan ng, jia xian law. (2025). comparing the growth kinetics and characteristics of wharton’s jelly derived mesenchymal stem cells expanded using different culture mediums. - cytotechnology. 1 - 16.
intan zarina zainol abidin, roa m.a. aliwaisi, zulham yamamoto, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). osteogenic potential in piper sarmentosum roxb.: a systematic review of in vitro and in vivo evidence. - sains malaysiana. 1875 - 1887.
intan zarina zainol abidin, thanaletchumi manogaran, rohaya megat abdul wahab, saiful anuar karsani, muhammad dain yazid, farinawati yazid, zaidah zainal ariffin, anis nabilah johari, shahrul hisham zainal ariffin. (2023). label-free quantitative proteomic analysis of ascorbic acid-induced differentially expressed osteoblast-related proteins in dental pulp stem cells from deciduous and permanent teeth. - current stem cell research & therapy. 417-428.
izyan mohd idris, fazlina nordin, nur jannaim muhamad, julaina abdul jalil, fatimah diana amin nordin, rosnani mohamed, adiratna mat ripen, gee jun tye, wan safwani wan kamarul zaman, muhammad dain yazid & min hwei ng. (2023). the establishment of in-vitro human induced pluripotent stem cell-derived neurons. - sains malaysiana. 849-862.
muhammad dain yazid, siti sarah azman, nadiah sulaiman, nur azurah abdul ghani, mohd ramzisham abdul rahman. (2023). optimisation of umbilical artery endothelial cells denudation for endothelial-vascular smooth muscle cells signalling ex vivo. - international journal of experimental pathology. 11.
intan zarina zainol abidin, roa m.a. aliwaisi, zulham yamamoto, muhammad dain yazid, shahrul hisham zainal ariffin. (2025). osteogenic potential in piper sarmentosum roxb.: a systematic review of in vitro and in vivo evidence. - sains malaysiana. 1875 - 1887.
muhammad najib fathi hassan, muhammad dain yazid, mohd heikal bin mohd yunus, yogeswaran lokanathan, min hwei ng, ruszymah bt hj idrus, yee loong tang, see nguan ng, jia xian law. (2025). comparing the growth kinetics and characteristics of wharton’s jelly derived mesenchymal stem cells expanded using different culture mediums. - cytotechnology. 1 - 16.
jun wei heng, muhammad dain yazid, mohd faizal ahmad, mohd ramzisham abdul rahman, nadiah sulaiman. (2024). decellularisation of human umbilical arteries: preserving matrix integrity for coronary grafts. - journal of molecular and cellular cardiology plus. 10 - 10.
anam anjum, muhammad dain yazid, muhammad fauzi daud, jalilah idris, angela min hwei ng, amaramalar selvi naicker, ohnmar htwe rashidah ismail, ramesh kumar athi kumar, yogeswaran lokanathan. (2024). neuroaidtm-ii (mlc901) promoted neurogenesis by activating the pi3k/akt/gsk-3ß signaling pathway in rat spinal cord injury models. - biomedicines. 1 - 21.
nur a’tiqah haron, mohamad fikeri ishak, muhammad dain yazid, ubashini vijakumaran, roszita ibrahim, raja zahratul azma raja sabudin, hafiza alauddin, nur ayub md ali, hairulfaizi haron, muhammad ishamuddin ismail, mohd ramzisham abdul rahman and nadiah sulaiman. (2024). exploring the potential of saphenous vein grafts ex vivo: a model for intimal hyperplasia and re-endothelialization. - journal of clinical medicine. 1 - 17.
duangjai tungmunnithum, yohei sasaki, aekkhaluck intharuksa. (2025). effects of hydroxytyrosol in endothelial functioning: a comprehensive review. - special issue reprint. 66 - 84.
law jia xian, muhammad dain yazid, muhammad najib fathi hassan, benson koh, sharen aini shamsuddin. (2024). cabaran dalam rawatan menggunakan sel stem. - . 73 - 86.
kok-yong chin, muhammad dain yazid, mohd hafidzul jasman, raynuha mahadevan & siti mariam bujang. (2022). chapter 19: teaching and assessing the personal and professional advancement of undergraduate medical students during the pandemic: challenges and opportunities. - . 235-250.
ling ling liau, qi hao looi, sue ping eng, muhammad dain yazid, nadiah sulaiman, mohd fauzi mh busra, min hwei ng, jia xian law. (2020). mesenchymal stem cells for the treatment of immune-mediated diseases. - . 178-210.
shiplu roy chowdhury, yogeswaran lokanathan, law jia xian, fauzi mh busra, muhammad dain yazid, nadiah sulaiman, gargy lahiry and md enamul hoque. (2020). 3d printed bioscaffolds for developing tissue-engineered constructs. - manufacturing engineering. 1 - 22.
law jia xian, muhammad dain yazid, muhammad najib fathi hassan, benson koh, sharen aini shamsuddin. (2024). cabaran dalam rawatan menggunakan sel stem. - . 73 - 86.
muhammad dain yazid. (2023). apabila otot manusia melemah. - sinar plus (medik) dalam akhbar sinar harian. 16-17.
shahrul hisham zainal ariffin, thanaletchumi manogaran, rohaya megat abdul wahab, saiful anuar karsani, intan zarina zainol abidin, farinawati yazid, muhammad dain yazid, zaidah zainal ariffin. (2022). profil protein sekretom sel stem pulpa gigi manusia semasa aruhan asid askorbik. - sains malaysiana. 2173-2186.
rabiatul adawiyah razali, nur qisya afifah veronica sainik, muhammad dain yazid, yogeswaran lokanathan, aminuddin saim, ruszymah haji idrus. (2017). olive: can it cure rhinosinusitis?. - 1st tissue engineering and regenerative medicine postgraduate symposium 2017. .
rohaya megat abdul wahab, farah amirah mohd nasri, intan zarina zainol abidin, zaidah zainal ariffin, muhammad dain yazid, shahrul hisham zainal ariffin. (2017). kesan penyimpanan sampel air liur terhadap kualiti dna genom. - sains malaysiana. 909-915.
yogeswaran a/l lokanathan;ruszymah binti haji idrus;norazlina binti mohamed;mohd heikal bin mohd yunus;shamsul azhar bin shah;anis ezdiana binti abdul aziz;ng min hwei;shiplu roy chowdhury;muhammad da`in bin yazid;chow yock ping;chin kok yong;law jia xian. (2024). program: identifying degenerative disease burden among elderly population in klang valley and innovative intervention modalities. sub project: animal study on the safety and efficacy of allogeneic mesenchymal stromal/ stem cell therapy in delaying the pr. - . .
yogeswaran a/l lokanathan;mohd rafizul bin mohd yusof;mohd heikal bin mohd yunus;ng min hwei;muhammad da`in bin yazid;chin kok yong;law jia xian;sharen @ sharen aini binti shamsuddin;mohd asyraf bin mat afandi;rabiatul adawiyah binti razali. (2024). efficacy study of allogeneic mesenchymal stem cell therapy for treatment for metabolic syndrome in animal model. - . .
nadiah binti sulaiman;ruszymah binti haji idrus;muhammad da`in bin yazid;mohamad fikeri bin ishak. (2023). investigating the effect of hydroxytyrosol in human inflamed respiratory epithelial in vitro: possible epithelial salvage for coronavirus disease 2019 (covid-19) patients with acute respiratory distress syndrome (ards). - . .
muhammad dain yazid. (2023). apabila otot manusia melemah. - sinar plus (medik) dalam akhbar sinar harian. 16-17.
yogeswaran a/l lokanathan;amaramalar selvi naicker;ohnmar htwe @ rashidah binti ismail;brenda saria binti yuliawiratman;ng min hwei;ramesh kumar a/l athi kumar;muhammad da`in bin yazid. (2023). effect of neuroaid (mlc 901) on spinal cord regeneration in in vivo spinal cord injury model and its mechanism of action. - . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| UNRAVELLING SUBCELLULAR DYNAMICS OF RICTOR FOR ACTIN REMODELLING IN DUCHENNE MUSCULAR DYSTROPHY (DMD) | ming medical services sdn bhd | 78.8% (2023-10-01 sehingga 2026-03-31) |
| UNRAVELLING SUBCELLULAR DYNAMICS OF RICTOR FOR ACTIN REMODELLING IN DUCHENNE MUSCULAR DYSTROPHY (DMD) | malaysian rare disorders society (mrds) | 78.8% (2023-10-01 sehingga 2026-03-31) |
| EXPLORING NEURONAL EXPANSION BY PHOENIXIN IN PARKINSON`S DISEASE IN VITRO MODEL | monash university | 78.8% (2023-10-01 sehingga 2026-03-31) |
| IN-VITRO EVALUATION OF EXOSOME-HYALURONIC ACID SYNERGY IN ORAL WOUND HEALING | wari technologies sdn. bhd. | 44.2% (2024-11-01 sehingga 2026-10-31) |
| ENDOTHELIALISATION OF VASCULAR GRAFTS WITH CORONARY ARTERY DISEASE PATIENT-DERIVED VERSUS HEALTHY DONOR ENDOTHELIAL CELLS | intran technologies sdn. bhd | 63.5% (2025-01-31 sehingga 2026-01-30) |