pensyarah universiti
jabatan fizik gunaan
No. Telefon Rasmi : 0389213833
No. rasmi:
UKM : 03 8921 5555
Biografi/ Biography :
Advances in sequencing techniques gave rise to the rapid increase of new sequences. Yet, resolving the protein structure is complicated and time-consuming, creating an ever-widening “Protein structure gap”. With a mission to narrow the gap using computational tools, Su Datt pursued his PhD in Bioinformatics at University College London. Obtaining a good template is key to the success of protein structure modelling. During his PhD, he developed a template searching protocol that produced higher percentages of good quality modes compared to the state-of-the-art template searching protocol. His modelling platform has been applied to model >70% of the structurally uncharacterised proteins for >14 model organisms.
After graduated from his PhD, he embarked on a study to understand the biological impacts of mutually exclusive exon splicing (MXE) in 5 different genomes. MXE-specific residues tend to be surface exposed and cluster near protein functional sites. MXEs tend to maintain the protein fold, but alter the specificity and selectivity of protein functions. These results suggest MXEs may have some important roles in cells and also in cancer. He recently acquired a research grant to study the structure of proteins found in a fungus living in Antarctica. Studying proteins found in harsh environment may lead to the finding of new enzymes that may be in industrial applications or possible bioproducts.
siti nur hidayah jamil, amatul hamizah ali, shevin rizal feroz, su datt lam, hani kartini agustar, mohd ridzuan mohd abd razak, jalifah latip. (2023). curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action. - pharmaceuticals. 1-25.
nicola bordin, ian sillitoe, vamsi nallapareddy, clemens rauer, su datt lam, vaishali p. waman, neeladri sen, michael heinzinger, maria littmann, stephanie kim, sameer velankar, martin steinegger, burkhard rost, christine orengo. (2023). alphafold2 reveals commonalities and novelties in protein structure space for 21 model organisms. - communications biology. 1-12.
aidil bin abdul hamid;farah diba bt. abu bakar;izyanti binti ibrahim;lam su datt;shazilah binti kamaruddin. (2023). elucidation of the dynamics of lipogenic metabolon formation in cunninghamella bainieri 2a1 and prediction of its structural organisation. - . .
danish sanuri, ahmad al-khdhairawi, rahmad akbar, su datt lam, shobana sugumar, nazlina ibrahim, sylvia chieng, fareed sairi. (2023). machine learning and molecular simulation ascertain antimicrobial peptide against klebsiella pneumoniae from public database. - computational biology and chemistry. 1-13.
yonathan goldtzvik, neeladri sen, su datt lam, christine orengo. (2023). protein diversification through post-translational modifications, alternative splicing, and gene duplication. - current opinion in structural biology. 1-10.
danish sanuri, ahmad al-khdhairawi, rahmad akbar, su datt lam, shobana sugumar, nazlina ibrahim, sylvia chieng, fareed sairi. (2023). machine learning and molecular simulation ascertain antimicrobial peptide against klebsiella pneumoniae from public database. - computational biology and chemistry. 1-13.
nicola bordin, ian sillitoe, vamsi nallapareddy, clemens rauer, su datt lam, vaishali p. waman, neeladri sen, michael heinzinger, maria littmann, stephanie kim, sameer velankar, martin steinegger, burkhard rost, christine orengo. (2023). alphafold2 reveals commonalities and novelties in protein structure space for 21 model organisms. - communications biology. 1-12.
siti nur hidayah jamil, amatul hamizah ali, shevin rizal feroz, su datt lam, hani kartini agustar, mohd ridzuan mohd abd razak, jalifah latip. (2023). curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action. - pharmaceuticals. 1-25.
yonathan goldtzvik, neeladri sen, su datt lam, christine orengo. (2023). protein diversification through post-translational modifications, alternative splicing, and gene duplication. - current opinion in structural biology. 1-10.
sarahani harun, nor afiqah aleng, fatin izzati abdul hadi , su datt lam, zeti azura mohamed hussein. (2022). identification of potential genes encoding protein transporters in arabidopsis thaliana glucosinolate (gsl) metabolism. - life. 1-17.
xin-wei lee, su datt lam, mohd firdaus-raih, kiew-lian wan. (2020). molecular characterisation of eimeria tenella porin, a potential anticoccidial drug target. - sains malaysiana. 755-764.
siti nur hidayah jamil, amatul hamizah ali, shevin rizal feroz, su datt lam, hani kartini agustar, mohd ridzuan mohd abd razak, jalifah latip. (2023). curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action. - pharmaceuticals. 1-25.
yonathan goldtzvik, neeladri sen, su datt lam, christine orengo. (2023). protein diversification through post-translational modifications, alternative splicing, and gene duplication. - current opinion in structural biology. 1-10.
nicola bordin, ian sillitoe, vamsi nallapareddy, clemens rauer, su datt lam, vaishali p. waman, neeladri sen, michael heinzinger, maria littmann, stephanie kim, sameer velankar, martin steinegger, burkhard rost, christine orengo. (2023). alphafold2 reveals commonalities and novelties in protein structure space for 21 model organisms. - communications biology. 1-12.
danish sanuri, ahmad al-khdhairawi, rahmad akbar, su datt lam, shobana sugumar, nazlina ibrahim, sylvia chieng, fareed sairi. (2023). machine learning and molecular simulation ascertain antimicrobial peptide against klebsiella pneumoniae from public database. - computational biology and chemistry. 1-13.
mia yang ang, nurul amirah binti mohamad farook, norhidayah kamarudin, su datt lam, sabrina di gregorio, tengku zetty maztura binti tengku jamaluddin, sheila nathan, muttaqillah najihan abdul samat, silvia argimn, hui-min neoh. (2022). draft genome sequences of four methicillin-resistant staphylococcus aureus strains (m080_2017, m106_2017, m181_2017, and m191_2017), isolated from a malaysian teaching hospital. - microbiology resource announcements. 1-2.
natalie l. dawson, ian sillitoe, jonathan g. lees, su datt lam & christine a. orengo. (2017). protein bioinformatics from protein modifications and networks to proteomics. - . 32.
aidil bin abdul hamid;farah diba bt. abu bakar;izyanti binti ibrahim;lam su datt;shazilah binti kamaruddin. (2023). elucidation of the dynamics of lipogenic metabolon formation in cunninghamella bainieri 2a1 and prediction of its structural organisation. - . .
lam su datt;mohd firdaus bin mohd raih. (2022). computational structural and functional annotation of the glaciozyma antarctica proteome. - . .
neoh hui-min, lam su datt, sheila nathan. (2022). pha4ge amr sub-award success story: team malaysia. - pha4ge newsletter. 4-5.
nurulhikma md isa, nur aminah mohd hazbir, sitti aisyah mohd roszelin, khairun nisa japlus, su datt lam ,sobri hussein. (2022). improving environmental resilience in crops for high yield production. - 3rd joint symposium on plant sciences and products. 3.
neoh hui-min, lam su datt, ang mia yang, sabrina noelia di gregorio, sheila nathan. (2022). implementation of standardized bioinformatics practices, pipelines, and data structures in amr sequencing laboratories in lmics. - . 1-3.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| ARTIFICIAL INTELLIGENCE PREDICTED 3D STRUCTURE-GUIDED FUNCTIONAL STUDIES TOWARDS BIOCHEMICAL CHARACTERISATION OF BURKHOLDERIA PSEUDOMALLEI HYPOTHETICAL PROTEINS | malaysia genome and vaccine institute (dr. anuar jonet) | 39.7% (2023-05-03 sehingga 2024-05-02) |