Biografi/ Biography :
My research is primarily directed at understanding molecular function regulation by exploring the mechanistic atomic level interactions that affect function and/or effect molecular level switching as well as the associated regulatory pathways. To accomplish this, my research group studies the structure, function and evolution of biological macromolecules to compare how the atomic level differences can result in different functions by effecting regulatory or mechanistic changes. We source our data from public repositories such as GenBank and the Protein Data Bank as well as by generating internal data such as genome sequences, transcriptome sequences and methylome sequences from specific experiments. The approaches employed in exploring and investigating these datasets primarily involve bioinformatics, computational biology and genomics but also extend to structural biology (mainly X-ray crystallography), synthetic biology and systems biology. The insights revealed from these investigations can provide clues as to how molecular level regulation and responses in living systems are carried out that eventually lead to an organism’s capacity to adapt to extreme (ie. extremophiles) or diverse environments (ie. such as a bacterial pathogen or parasite adapting to a host) as well as the discovery of novel factors associated with pathogenesis (toxins and pathogenesis/virulence regulation systems). Our understanding of the atomic level interactions that define specific biological mechanisms have led to the development of applications for drug repositioning and tools for the synthetic design of nucleic acid self-assembling structures.
harishaa thangarajan, mohd firdaus mohd raih, sabrina mohamed moffi, doris quay huai xia, lam kok wai, mohd anuar jonet, chyan leong ng. (2024). structural characterization of alternative sites for drug repurposing against antibiotic-resistant bacteria. - asian regional conference on systems biology 2023. 57.
nik yusnoraini yusof, doris huai xia quay, shazilah kamaruddin, mohd anuar jonet, rosli md illias, nor muhammad mahadi, mohd firdaus-raih, farah diba abu bakar, abdul munir abdul murad. (2024). biochemical and in silico structural characterization of a cold-active arginase from the psychrophilic yeast, glaciozyma antarctica pi12. - extremophiles. 1-13.
pravin kumran nyanasegran, sheila nathan, mohd firdaus raih, nor azlan nor muhammad, chyan leong ng. (2024). structural and functional characterisation of the burkholderia pseudomallei biofilm biosynthesis-related hypothetical protein bpsl0610. - asian regional conference on systems biology 2023. 46.
naif h. al-hardan, muhammad azmi abdul hamid, mohd firdaus-raih, azman jalar, ain zafirah kamaruddin, lim kar keng, ensaf mohammed al-khalqi, naser m. ahmed. (2024). titanium dioxide ion-sensitive extended gate field effect transistor (isegfet): selective detection of potassium ions in artificial blood serum. - journal of materials science: materials in electronics. 1-16.
nur afiqah shalihin muhamad ismail, su hui yap, mohamad ariff mohamad yussoff, nor azlan nor muhammad, mohd firdaus-raih, doris huai xia quay. (2023). modeling and computational characterization of a xanthomonas sp. hypothetical protein identifies a remote ortholog of burkholderia lethal factor 1. - journal of biomolecular structure and dynamics. 1-14.
naif h. al-hardan, muhammad azmi abdul hamid, mohd firdaus-raih, azman jalar, ain zafirah kamaruddin, lim kar keng, ensaf mohammed al-khalqi, naser m. ahmed. (2024). titanium dioxide ion-sensitive extended gate field effect transistor (isegfet): selective detection of potassium ions in artificial blood serum. - journal of materials science: materials in electronics. 1-16.
sofiyah shaibullah; nurshahirah shuhaimi; de-sheng ker; nurhikmah mohd-sharif; kok lian ho; aik-hong the; jitka waterman; thean-hock tang; rui-rui wong; sheila nathan; rahmah mohamed; min jia ng; shin-yee fung; mohd firdaus-raih; chyan leong ng; et. al. (2023). structural and functional analyses of burkholderia pseudomallei bpsl1038 reveal a cas-2/vapd nuclease sub-family. - communications biology. 1-15.
ahmad-kamal ghazali, mohd firdaus-raih, asqwin uthaya kumar, wei-kang lee, chee-choong hoh, sheila nathan. (2023). transitioning from soil to host: comparative transcriptome analysis reveals the burkholderia pseudomallei response to different niches. - microbiology spectrum. 1-21.
naif h. al-hardan, mohd firdaus-raih, muhammad azmi abdul hamid, azman jalar. (2023). real-time viral detection through electrolyte-gated field effect transistors: possibility of rapid covid-19 detection. - critical reviews in solid state and materials sciences. 194-220.
mursyidah, a.-k., hafizzudin-fedeli, m., nor muhammad, n.a., latiff, a., firdaus-raih, m., wan, k.-l.. (2023). dissecting the biology of rafflesia species: current progress and future directions made possible with high-throughput sequencing data. - plant and cell physiology. 368-377.
nik yusnoraini yusof, doris huai xia quay, shazilah kamaruddin, mohd anuar jonet, rosli md illias, nor muhammad mahadi, mohd firdaus-raih, farah diba abu bakar, abdul munir abdul murad. (2024). biochemical and in silico structural characterization of a cold-active arginase from the psychrophilic yeast, glaciozyma antarctica pi12. - extremophiles. 1-13.
pravin kumran nyanasegran, sheila nathan, mohd firdaus raih, nor azlan nor muhammad, chyan leong ng. (2023). biofilm signaling, composition and regulation in burkholderia pseudomallei. - journal of microbiology and biotechnology. 15-27.
siti asmaa mat jusoh, danesh thangeswaran, muhammad syahir hakimi mohd hazli, mohd firdaus raih, nurulasma abdullah, shaharum shamsuddin. (2022). construction of multi-epitopes vaccine candidate against sars-cov-2 d614g variant. - sains malaysiana. 2985-2997.
hafizzudin-fedeli, m., abu-bakar, m.-f., mat-isa, m.-n., latiff, a., firdaus-raih, m., wan, k.-l.. (2022). characterisation of tetrastigma rafflesiae mitochondrial genes and assessment of their potential as sequence markers. - sains malaysiana. 2435-2447.
noor munyati othman, sri d. appasamy, nadzirah damiri, reeki emrizal, norfarrah mohamed alipiah, effirul ikhwan ramlan, mohd firdaus raih. (2021). regulation of glycine cleavage and detoxification by a highly conserved glycine riboswitch in burkholderia spp. - current microbiology. 2943-2955.
nik yusnoraini yusof, doris huai xia quay, shazilah kamaruddin, mohd anuar jonet, rosli md illias, nor muhammad mahadi, mohd firdaus-raih, farah diba abu bakar, abdul munir abdul murad. (2024). biochemical and in silico structural characterization of a cold-active arginase from the psychrophilic yeast, glaciozyma antarctica pi12. - extremophiles. 1-13.
naif h. al-hardan, muhammad azmi abdul hamid, mohd firdaus-raih, azman jalar, ain zafirah kamaruddin, lim kar keng, ensaf mohammed al-khalqi, naser m. ahmed. (2024). titanium dioxide ion-sensitive extended gate field effect transistor (isegfet): selective detection of potassium ions in artificial blood serum. - journal of materials science: materials in electronics. 1-16.
naif h. al-hardan, mohd firdaus-raih, muhammad azmi abdul hamid, azman jalar. (2023). real-time viral detection through electrolyte-gated field effect transistors: possibility of rapid covid-19 detection. - critical reviews in solid state and materials sciences. 194-220.
nur afiqah shalihin muhamad ismail, su hui yap, mohamad ariff mohamad yussoff, nor azlan nor muhammad, mohd firdaus-raih, doris huai xia quay. (2023). modeling and computational characterization of a xanthomonas sp. hypothetical protein identifies a remote ortholog of burkholderia lethal factor 1. - journal of biomolecular structure and dynamics. 1-14.
sofiyah shaibullah; nurshahirah shuhaimi; de-sheng ker; nurhikmah mohd-sharif; kok lian ho; aik-hong the; jitka waterman; thean-hock tang; rui-rui wong; sheila nathan; rahmah mohamed; min jia ng; shin-yee fung; mohd firdaus-raih; chyan leong ng; et. al. (2023). structural and functional analyses of burkholderia pseudomallei bpsl1038 reveal a cas-2/vapd nuclease sub-family. - communications biology. 1-15.
siuk-mun ng, xin-wei lee, kiew-lian wan & mohd firdaus-raih. (2015). comparative differential gene expression analysis of nucleus-encoded proteins for rafflesia cantleyi against arabidopsis thaliana. - the 2015 ukm fst postgraduate colloquium. 030020(1-6).
intan azlinda ramlee, mohd firdaus-raih & kiew-lian wan. (2015). identification and characterization of secreted proteins in eimeria tenella. - aip conference proceedings. 030023.
noor munyati othman, ahmad luqman abdul fatah, mohd al akmarul fizree bin md piji, effirul ikhwan ramlan and mohd firdaus raih. (2015). identification and cloning of four riboswitches from burkholderia pseudomallei strain k96243. - the 2015 ukm fst postgraduate colloquium. 1-5.
nur syamimi yusoff, nadzirah damiri, mohd firdaus-raih. (2014). identification of the conserved hypothetical protein bpsl0317 in burkholderia pseudomallei k96243. - aip conference proceeding - the 2014 ukm fst postgraduate colloquium. 544-548.
faridah hani mohamed salleh, suhaila zainudin,mohd firdaus raih. (2021). model regresi untuk pembinaan semula rangkaian pengawal atur gen. - . 162.
shuhaila mat-sharani, doris hx quay, chyan l ng & mohd firdaus-raih. (2019). encyclopedia of bioinformatics and computational biology. - . 7.
nur sa ghani, shandar ahmad, mohd firdaus-raih. (2018). encyclopedia of bioinformatics and computational biology. - . 9.
munyati othman, siuk m ng, mohd firdaus-raih. (2018). encyclopedia of bioinformatics and computational biology. - . 5.
suhaila sulaiman, nur s yusoff, ng s mun, haslina makmur, mohd firdaus-raih. (2018). encyclopedia of bioinformatics and computational biology. - . 11.
chyan leong ng & mohd firdaus-raih. (2019). encyclopedia of bioinformatics and computational biology. - . 14.
shuhaila mat-sharani, doris hx quay, chyan l ng & mohd firdaus-raih. (2019). encyclopedia of bioinformatics and computational biology. - . 7.
munyati othman, siuk m ng, mohd firdaus-raih. (2018). encyclopedia of bioinformatics and computational biology. - . 5.
mohd firdaus-raih, nur syatila abdul ghani. (2018). encyclopedia of bioinformatics and computational biology. - . 10.
nur sa ghani, shandar ahmad, mohd firdaus-raih. (2018). encyclopedia of bioinformatics and computational biology. - . 9.
faridah hani mohamed salleh, suhaila zainudin,mohd firdaus raih. (2021). model regresi untuk pembinaan semula rangkaian pengawal atur gen. - . 162.
idayu maarof, mohd firdaus raih. (2021). a consequence of sequence. - . 204.
idayu maarof, mohd firdaus raih. (2016). the doctor is sick. - . 128.
harishaa thangarajan, mohd firdaus mohd raih, sabrina mohamed moffi, doris quay huai xia, lam kok wai, mohd anuar jonet, chyan leong ng. (2024). structural characterization of alternative sites for drug repurposing against antibiotic-resistant bacteria. - asian regional conference on systems biology 2023. 57.
pravin kumran nyanasegran, sheila nathan, mohd firdaus raih, nor azlan nor muhammad, chyan leong ng. (2024). structural and functional characterisation of the burkholderia pseudomallei biofilm biosynthesis-related hypothetical protein bpsl0610. - asian regional conference on systems biology 2023. 46.
wan kiew lian;mohd firdaus bin mohd raih. (2023). genomic sequence diversity in the eimeria surface antigen superfamily. - . .
kalaivani a/p k. nadarajah;mohd firdaus bin mohd raih. (2023). in silico mapping of qtls associated with resistance against biotic and abiotic stresses. - . .
ng chyan leong;sheila nathan;mohd firdaus bin mohd raih. (2023). structural and functional characterization of genes encoding hypothetical proteins but are essential for host infection in burkholderia pseudomallei . - . .